Liu Chungang, Zeng Xuerui, Li Yi, Ma Hongli, Song Jingjing, Li Yuhuan, Zhou Yulin, Lee Robert J, Wang Di
School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
Mol Med Rep. 2017 May;15(5):2807-2813. doi: 10.3892/mmr.2017.6311. Epub 2017 Mar 10.
Due to its pharmacological activities, Paecilomyces tenuipes has previously been used as a folk medicine in Asia. The primary aim of the present study was to investigate the hypoglycemic, hypolipidemic and anti‑nephritic effects of P. tenuipes N45 aqueous extracts (PTNE) in a high fat diet/streptozotocin‑induced diabetic rat model. The rats were treated with 120 mg/kg of metformin or 0.04, 0.2 or 1.0 g/kg PTNE for 4 weeks. The hypoglycemic activity of PTNE was confirmed by the observation of reduced fasting blood glucose level and by partially normalized oral glucose tolerance. PTNE reduced total cholesterol and triglyceride content, and balanced the levels of low‑density and high‑density lipoproteins. The suppressive effects of PTNE on creatinine, blood urea nitrogen, interleukin (IL)‑2, IL‑6 and nuclear factor‑κB levels indicated its ability to provide protection against diabetic nephropathy. PTNE treatment increased superoxide dismutase, malondialdehyde and glutathione peroxidase levels, suggesting that its anti‑diabetic and anti‑nephropathic activities may be associated with the prevention of oxidative damage during type 2 diabetic mellitus. The findings of the present study provided experimental evidence for the application of Paecilomyces tenuipes N45 on the treatment of type 2 diabetic mellitus.
由于其药理活性，细脚拟青霉此前在亚洲被用作民间药物。本研究的主要目的是在高脂肪饮食/链脲佐菌素诱导的糖尿病大鼠模型中，研究细脚拟青霉N45水提取物（PTNE）的降血糖、降血脂和抗肾炎作用。大鼠分别用120 mg/kg二甲双胍或0.04、0.2或1.0 g/kg PTNE治疗4周。通过观察空腹血糖水平降低和口服葡萄糖耐量部分恢复正常，证实了PTNE的降血糖活性。PTNE降低了总胆固醇和甘油三酯含量，并平衡了低密度和高密度脂蛋白水平。PTNE对肌酐、血尿素氮、白细胞介素（IL）-2、IL-6和核因子-κB水平的抑制作用表明其具有预防糖尿病肾病的能力。PTNE治疗增加了超氧化物歧化酶、丙二醛和谷胱甘肽过氧化物酶水平，表明其抗糖尿病和抗肾病活性可能与预防2型糖尿病期间的氧化损伤有关。本研究结果为细脚拟青霉N45在2型糖尿病治疗中的应用提供了实验证据。
