Durham Phillip G, Hanif Shumaila N, Contreras Lucia Garcia, Young Ellen F, Braunstein Miriam S, Hickey Anthony J
RTI International;
Oklahoma University Health Science Center.
J Vis Exp. 2017 Mar 30(121):55356. doi: 10.3791/55356.
Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs locally and systemically. Evaluation of dry powder aerosols necessitates an efficient dispersion mechanism to maintain high concentrations in an exposure chamber or for direct endotracheal administration. While solutions exist to expose animals by passive inhalation to dry powder aerosols, most require masses of powder in large excess of the dose delivered. This precludes conducting early feasibility studies as insufficient drug is available at the research or early development stage to support the dose delivery requirements for conventional aerosol delivery systems. When designing an aerosol drug product, aerodynamic performance can relate directly to delivery efficiency and efficacy. Dispersion of powder into an aerosol requires energy input sufficient to overcome interparticulate forces, and particle engineering approaches can substantially improve aerosol performance. We have developed a dispersion system (dosator) which can aerosolize engineered dry powder aerosols efficiently for the purpose of direct pulmonary insufflation, dispersion into an exposure system or generation for analytical purposes.
新型治疗产品的研发需要在动物模型中进行疗效测试。肺部给药途径可用于局部和全身给药。对干粉气雾剂的评估需要一种有效的分散机制，以在暴露舱中或直接气管内给药时维持高浓度。虽然存在通过被动吸入使动物暴露于干粉气雾剂的方法，但大多数方法所需的粉末量远远超过给药剂量。这使得早期可行性研究无法进行，因为在研究或早期开发阶段没有足够的药物来支持传统气雾剂给药系统的剂量输送要求。在设计气雾剂药物产品时，空气动力学性能可能直接关系到输送效率和疗效。将粉末分散成气雾剂需要足够的能量输入以克服颗粒间的作用力，而颗粒工程方法可以显著提高气雾剂性能。我们开发了一种分散系统（定量给药器），该系统可以有效地将工程化干粉气雾剂雾化，用于直接肺部吹入、分散到暴露系统中或用于分析目的的生成。
