a Cellular and Molecular Research Center, Zahedan University of Medical Sciences , Zahedan , Iran.
b Department of Clinical Biochemistry , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
Clin Exp Hypertens. 2017;39(3):220-224. doi: 10.1080/10641963.2016.1235182.
Estrogen receptor-α (ERα) plays an essential role in the adaptation of increased uterine blood flow during gestation. Therefore, ERα gene could be a possible candidate for preeclampsia (PE) susceptibility. In current study we aimed to investigate the association of the ERα gene polymorphisms and PE in an Iranian population.
A total of 192 pregnant women with PE and 186 normotensive women were genotyped for ERα gene (PvuII and XbaI) polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method.
The frequencies of alleles and genotypes of ERα PvuII and XbaI polymorphisms were not different between PE and normotensive control women. However, higher frequency of GG genotype was observed in women with severe PE compared to mild PE (OR, 1.8 [95% CI, 1.1 to 3]; p = 0.02) and in severe PE compared to normotensive women [OR = 1.8 (1.1-3), p = 0.02] after adjusting for age, ethnicity, and primiparity.
The GG genotype of ERα XbaI polymorphism could be a genetic risk factor for PE predisposition.
雌激素受体-α（ERα）在妊娠期间增加子宫血流适应中起着至关重要的作用。因此，ERα 基因可能是先兆子痫（PE）易感性的候选基因之一。在本研究中，我们旨在调查伊朗人群中 ERα 基因多态性与 PE 的关联。
采用聚合酶链反应-限制性片段长度多态性方法，对 192 例 PE 孕妇和 186 例正常血压孕妇的 ERα 基因（PvuII 和 XbaI）多态性进行基因分型。
PE 组和正常血压对照组的 ERα PvuII 和 XbaI 多态性的等位基因和基因型频率无差异。然而，与轻度 PE 相比，重度 PE 患者 GG 基因型的频率更高（OR，1.8 [95%CI，1.1 至 3]；p = 0.02），与正常血压孕妇相比，重度 PE 患者 GG 基因型的频率也更高（OR = 1.8 [1.1-3]，p = 0.02），调整年龄、种族和初产妇后。
ERα XbaI 多态性的 GG 基因型可能是 PE 易感性的遗传危险因素。
