Bagci Binnur, Karakus Savas, Bagci Gokhan, Sancakdar Enver
Department of Nutrition and Dietetics, Faculty of Health Sciences, Cumhuriyet University, 58140 Sivas, Turkey; Advanced Technology Research Center (CÜTAM), Cumhuriyet University, 58140 Sivas, Turkey.
Department of Obstetrics and Gynecology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
Pregnancy Hypertens. 2016 Apr;6(2):115-20. doi: 10.1016/j.preghy.2016.04.002. Epub 2016 Apr 19.
Renalase is a novel enzyme that degrades circulating catecholamines. We aimed to investigate the role of rs2576178 and rs10887800 polymorphisms of the renalase gene in preeclampsia (PE) patients
This case-control study consisted of 110 women with PE and 102 normotensive controls. PCR-RFLP method was used for determination of renalase gene polymorphisms.
Allele frequency and genotype distribution of rs10887800 polymorphism were found statistically significantly higher in women with PE (p<0.05). Also G allele and GG genotype of rs10887800 polymorphism were found higher in women with severe PE than that of mild PE (p<0.05). There was no significant difference for rs2576178 polymorphism in terms of allele frequency and genotype distribution (p>0.05). In PE patients, systolic blood pressure (SBP) means according to rs10887800 genotypes were found statistically significantly higher (GG vs AA; p=0.001) and (GG vs GA; p=0.001). Similarly, diastolic blood pressure (DBP) means were found statistically significantly higher in PE patients (GG vs GA: p=0.001); (GG vs AA: p=0.004). For rs2576178 polymorphism, SBP means were found as (GG vs AA; p=0.012, GG vs GA; p>0.05) in PE patients. DBP means were not significant according to rs2576178 genotypes in PE patients (p>0.05).
The findings of the present study suggest that blood pressure may be increased by GG genotype and G allele of rs10887800 polymorphism and the polymorphism may increase the susceptibility to PE.
肾酶是一种可降解循环儿茶酚胺的新型酶。我们旨在研究肾酶基因rs2576178和rs10887800多态性在子痫前期（PE）患者中的作用。
本病例对照研究纳入了110例PE女性患者和102例血压正常的对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测肾酶基因多态性。
rs10887800多态性的等位基因频率和基因型分布在PE女性患者中具有统计学显著差异（p<0.05）。此外，rs10887800多态性的G等位基因和GG基因型在重度PE女性患者中高于轻度PE患者（p<0.05）。rs2576178多态性在等位基因频率和基因型分布方面无显著差异（p>0.05）。在PE患者中，根据rs10887800基因型的收缩压（SBP）均值具有统计学显著差异（GG与AA比较；p=0.001）以及（GG与GA比较；p=0.001）。同样，PE患者的舒张压（DBP）均值也具有统计学显著差异（GG与GA比较：p=0.001）；（GG与AA比较：p=0.004）。对于rs2576178多态性，PE患者的SBP均值为（GG与AA比较；p=0.012，GG与GA比较；p>0.05）。根据rs2576178基因型，PE患者的DBP均值无显著差异（p>0.05）。
本研究结果表明，rs10887800多态性的GG基因型和G等位基因可能会使血压升高，且该多态性可能会增加患PE的易感性。
