Marzban Bahador, Yuan Hongyan
Department of Mechanical, Industrial & Systems Engineering, University of Rhode Island, Kingston, RI 02881, USA.
Membranes (Basel). 2017 Apr 27;7(2):24. doi: 10.3390/membranes7020024.
Mechanics of the bilayer membrane play an important role in many biological and bioengineering problems such as cell-substrate and cell-nanomaterial interactions. In this work, we study the effect of thermal fluctuation and the substrate elasticity on the cell membrane-substrate adhesion. We model the adhesion of a fluctuating membrane on an elastic substrate as a two-step reaction comprised of the out-of-plane membrane fluctuation and the receptor-ligand binding. The equilibrium closed bond ratio as a function of substrate rigidity was computed by developing a coupled Fourier space Brownian dynamics and Monte Carlo method. The simulation results show that there exists a crossover value of the substrate rigidity at which the closed bond ratio is maximal.
双层膜的力学在许多生物学和生物工程问题中起着重要作用，如细胞与基质以及细胞与纳米材料的相互作用。在这项工作中，我们研究了热涨落和基质弹性对细胞膜与基质粘附的影响。我们将波动膜在弹性基质上的粘附建模为一个由面外膜波动和受体 - 配体结合组成的两步反应。通过开发一种耦合傅里叶空间布朗动力学和蒙特卡罗方法，计算了作为基质刚度函数的平衡闭合键比率。模拟结果表明，存在一个基质刚度的交叉值，在该值处闭合键比率最大。
