Oh Tae Ryom, Kim Chang Seong, Bae Eun Hui, Ma Seong Kwon, Han Seung Hyeok, Sung Su-Ah, Lee Kyubeck, Oh Kook Hwan, Ahn Curie, Kim Soo Wan
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Depatment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
PLoS One. 2017 Apr 27;12(4):e0174282. doi: 10.1371/journal.pone.0174282. eCollection 2017.
Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.
维生素D缺乏在普通人群和慢性肾脏病（CKD）患者中都是一个日益严重的健康问题。然而，CKD患者血清25-羟维生素D水平与健康相关生活质量之间的关系尚未明确确立。本研究调查了透析前CKD患者维生素D缺乏与生活质量之间的关联。在韩国慢性肾脏病患者预后前瞻性队列研究（KNOW-CKD）中，对1844例透析前CKD患者测定了血清25-羟维生素D水平和韩国版肾脏病生活质量简表。基线估计肾小球滤过率为50.26±0.71ml/min/1.73m²。我们确定了1294例（70.2%）维生素D缺乏患者，定义为25-羟维生素D水平<20ng/ml。维生素D缺乏组的肾脏病成分总结、身体成分总结和精神成分总结得分显著低于无维生素D缺乏者。血清25-羟维生素D水平与肾脏病成分总结和精神成分总结得分独立相关（β=0.147，p=0.003；β=0.151，p=0.047）。总之，透析前CKD患者血清25-羟维生素D水平与肾脏病成分总结和精神成分总结得分之间存在显著关联。
