Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, UK.
University of Southampton, University Road, Southampton, SO17 1BJ, UK.
Qual Life Res. 2019 Jun;28(6):1565-1573. doi: 10.1007/s11136-019-02104-0. Epub 2019 Jan 12.
Health-related quality of life (HRQoL) is an important, patient-centred measure. Although nutritional status is altered in children with CKD, the impact of nutritional status on HRQoL in this population has not been explored. The aims of this study are to report the HRQoL scores as assessed by the validated PedsQL™ questionnaire and to explore the relationship of HRQoL scores to markers of nutritional status. It will also examine the concordance between the scores of the child and their parent/carer.
A single-centre, cross-sectional, observational study was performed exploring the markers of nutritional status (anthropometry-including presence of obesity, micronutrient status and appetite) and HRQoL and assessed by the PedsQL™ questionnaire in children aged 3-18 years with pre-dialysis, conservatively managed CKD.
A total of 46 children were recruited, with a mean age of 10.5 years. HRQoL scores were lower than in healthy controls throughout all domains. Lower scores were associated with short stature and poor appetite. Markers of obesity or micronutrient status were not associated with HRQoL scores.
Nutritional status impacts upon HRQoL. Further study is needed to evaluate how changing nutritional status may affect HRQoL in children with CKD, and this may be used to facilitate the development of patient-centred treatment goals and plans.
健康相关生活质量（HRQoL）是一个重要的、以患者为中心的衡量标准。尽管慢性肾脏病（CKD）患儿的营养状况发生了改变，但营养状况对该人群 HRQoL 的影响尚未得到探索。本研究的目的是报告经验证的 PedsQL™问卷评估的 HRQoL 评分，并探讨 HRQoL 评分与营养状况标志物的关系。它还将检查儿童及其父母/照顾者的分数之间的一致性。
进行了一项单中心、横断面、观察性研究，探索了营养状况标志物（人体测量学，包括肥胖、微量营养素状况和食欲）和 HRQoL，并使用 PedsQL™问卷评估了 3-18 岁接受保守治疗的、未接受透析的 CKD 儿童。
共招募了 46 名儿童，平均年龄为 10.5 岁。在所有领域，HRQoL 评分均低于健康对照组。较低的评分与身材矮小和食欲不振有关。肥胖或微量营养素状况的标志物与 HRQoL 评分无关。
营养状况会影响 HRQoL。需要进一步研究来评估营养状况的变化如何影响 CKD 儿童的 HRQoL，这可能用于促进以患者为中心的治疗目标和计划的制定。
