Han Dong, Qiao Zhengxue, Chen Lu, Qiu Xiaohui, Fang Deyu, Yang Xiuxian, Ma Jingsong, Chen Mingqi, Yang Jiarun, Wang Lin, Zhu Xiongzhao, Zhang Congpei, Yang Yanjie, Pan Hui
Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang Province, China.
Peking Union Medical College Hospital, Beijing, China.
J Affect Disord. 2017 Aug 1;217:295-298. doi: 10.1016/j.jad.2017.04.028. Epub 2017 Apr 19.
Recent studies suggest that vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder. The aim of this study is to investigate the interaction between vascular endothelial growth factor (VEGF) polymorphism (+405G/C, rs2010963) and negative life events in the pathogenesis of major depressive disorder (MDD).
DNA genotyping was performed on peripheral blood leukocytes in 274 patients with MDD and 273 age-and sex-matched controls. The frequency and severity of negative life events were assessed by the Life Events Scale (LES). A logistics method was employed to assess the gene-environment interaction (G×E).
Differences in rs2010963 genotype distributions were observed between MDD patients and controls. Significant G×E interactions between allelic variation of rs2010963 and negative life events were observed. Individuals carrying the C alleles were susceptible to MDD only when exposed to high-negative life events.
These results indicate that interactions between the VEGF rs2010963 polymorphism and environment increases the risk of developing MDD.
近期研究表明血管内皮生长因子（VEGF）参与了重度抑郁症的发病过程。本研究旨在探讨血管内皮生长因子（VEGF）基因多态性（+405G/C，rs2010963）与负性生活事件在重度抑郁症（MDD）发病机制中的相互作用。
对274例MDD患者及273例年龄和性别匹配的对照者的外周血白细胞进行DNA基因分型。采用生活事件量表（LES）评估负性生活事件的频率和严重程度。采用logistic方法评估基因-环境相互作用（G×E）。
观察到MDD患者与对照者之间rs2010963基因型分布存在差异。观察到rs2010963等位基因变异与负性生活事件之间存在显著的G×E相互作用。仅当暴露于高负性生活事件时，携带C等位基因的个体易患MDD。
这些结果表明VEGF rs2010963基因多态性与环境之间的相互作用增加了患MDD的风险。
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