Andreano Joseph M, Touroutoglou Alexandra, Dickerson Bradford C, Barrett Lisa F
Athinoula A. Martinos Center for Biomedical Imaging.
Psychiatric Neuroimaging Division, Department of Psychiatry.
Soc Cogn Affect Neurosci. 2017 Jun 1;12(6):948-955. doi: 10.1093/scan/nsx026.
The resting connectivity of the brain's salience network, particularly the ventral subsystem of the salience network, has been previously associated with various measures of affective reactivity. Numerous studies have demonstrated that increased affective arousal leads to enhanced consolidation of memory. This suggests that individuals with greater ventral salience network connectivity will exhibit greater responses to affective experience, leading to a greater enhancement of memory by affect. To test this hypothesis, resting ventral salience connectivity was measured in 41 young adults, who were then exposed to neutral and negative affect inductions during a paired associate memory test. Memory performance for material learned under both negative and neutral induction was tested for correlation with resting connectivity between major ventral salience nodes. The results showed a significant interaction between mood induction (negative vs neutral) and connectivity between ventral anterior insula and pregenual anterior cingulate cortex, indicating that salience node connectivity predicted memory for material encoded under negative, but not neutral induction. These findings suggest that the network state of the perceiver, measured prior to affective experience, meaningfully influences the extent to which affect modulates memory. Implications of these findings for individuals with affective disorder, who show alterations in both connectivity and memory, are considered.
大脑突显网络的静息态连接性，尤其是突显网络的腹侧子系统，此前已与多种情感反应指标相关联。大量研究表明，情感唤醒增强会导致记忆巩固增强。这表明腹侧突显网络连接性更强的个体对情感体验的反应会更大，从而情感对记忆的增强作用也会更大。为了验证这一假设，对41名年轻人测量了静息态腹侧突显连接性，然后在配对联想记忆测试中让他们接受中性和负面情感诱导。测试了在负面和中性诱导下学习的材料的记忆表现与主要腹侧突显节点之间静息态连接性的相关性。结果显示，情绪诱导（负面与中性）与腹侧前岛叶和膝前扣带回皮质之间的连接性存在显著交互作用，表明突显节点连接性可预测在负面而非中性诱导下编码材料的记忆。这些发现表明，在情感体验之前测量的感知者网络状态会显著影响情感对记忆的调节程度。本文还考虑了这些发现对情感障碍患者的意义，这类患者在连接性和记忆方面均存在改变。
