Fennelly Joseph, Potter Lauren, Pompili Cecilia, Brunelli Alessandro
Department of Thoracic Surgery, St. James's University Hospital, Leeds, UK.
Section of Patient Centered Outcomes Research, Leeds Institute of Cancer and Pathology, Leeds, UK.
J Thorac Dis. 2017 Mar;9(3):789-795. doi: 10.21037/jtd.2017.03.22.
The current functional guidelines recommend the shuttle walk test (SWT) as an initial screening tool to identify candidates for lung resection without requiring cardiopulmonary exercise testing. This study aims to: (I) assess the use of the SWT in predicting postoperative cardiopulmonary complications; and (II) determine whether the recommended 400 m cut-off is an appropriate distance.
We retrospectively analysed 101 patients that had performed a SWT prior to surgery. Univariate and multivariate regression analyses were used to test associations between patient variables [demographics, pre-existing conditions, pulmonary function, oxygen desaturation during the SWT, shuttle walk distance (SWD)] and post-operative cardiopulmonary complications.
Patients without cardiopulmonary complications walked longer distance compared to those with complication (417.3 348.6 m, P=0.01. Fifty two patients walked less than 400 m and 16 less than 250 m. Only 10% of patients who walked at least 400 m had cardiopulmonary complications compared to 33% of those who did not reach this distance (P=0.008). Half of the patients who walked less than 400 m and desaturated during the exercise developed cardiopulmonary complications. A SWD shorter than 400 m remained the only factor significantly associated with cardiopulmonary complications (P=0.009, OR: 4.3) after logistic regression analysis.
Our results support the use of the SWT as an initial screening tool in all patients prior to lung resection. Patients walking longer than 400 m experienced very low incidence of complications and would not need further testing prior to proceed to lung resection.
当前的功能指南推荐穿梭步行试验(SWT)作为初步筛查工具,用于识别肺切除手术的候选者,而无需进行心肺运动测试。本研究旨在:(I)评估SWT在预测术后心肺并发症方面的应用;(II)确定推荐的400米临界值是否为合适的距离。
我们回顾性分析了101例术前进行过SWT的患者。采用单因素和多因素回归分析来检验患者变量[人口统计学、既往疾病、肺功能、SWT期间的氧饱和度下降、穿梭步行距离(SWD)]与术后心肺并发症之间的关联。
无心肺并发症的患者比有并发症的患者步行距离更长(417.3±348.6米,P = 0.01)。52例患者步行距离小于400米,16例小于250米。步行至少400米的患者中只有10%发生心肺并发症,而未达到此距离的患者中这一比例为33%(P = 0.008)。在运动期间步行距离小于400米且出现氧饱和度下降的患者中,有一半发生了心肺并发症。经过逻辑回归分析,SWD短于400米仍然是与心肺并发症显著相关的唯一因素(P = 0.009,OR:4.3)。
我们的结果支持在所有肺切除术前患者中使用SWT作为初步筛查工具。步行距离超过400米的患者并发症发生率极低,在进行肺切除术前无需进一步检查。