Cui Yin, Prabhu Vishwanath Vasudev, Nguyen Thong Ba, Devi Subramaniam Mohana, Chung Young-Chul
Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea.
Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):146-152. doi: 10.9758/cpn.2017.15.2.146.
To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] ≤5 years) or chronic (DI >5 years) psychosis using T lymphocytes.
Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis. Additionally, smoking, metabolic syndrome, depression, and cognitive functioning were assessed to control for confounding effects.
TL was significantly longer in patients with early and chronic psychosis than in healthy control subjects and, moreover, the significance of these findings remained after controlling for age, smoking, metabolic syndrome, DI, chlorpromazine-equivalent dose, and cognitive functioning (F=9.57, degree of freedom=2, <0.001). Additionally, the DI, chlorpromazine-equivalent doses, and the five-factor scores of the Positive and Negative Syndrome Scale were not significantly correlated with the TL of T lymphocytes in either all patients or each psychosis group.
Possible mechanisms underlying the effects of antipsychotic medications on telomerase are discussed in the present study, but further studies measuring both telomerase activity and TL using a prospective design will be required.
研究作为促炎细胞因子和细胞毒性物质来源的病理状况，以使用T淋巴细胞检测早期（病程[DI]≤5年）或慢性（DI>5年）精神病患者的端粒长度（TL）。
基于这些因素以及T淋巴细胞在炎症中所起的重要作用，本研究测量了早期或慢性精神病患者T淋巴细胞的TL。此外，对吸烟、代谢综合征、抑郁和认知功能进行评估以控制混杂效应。
早期和慢性精神病患者的TL显著长于健康对照受试者，而且，在控制年龄、吸烟、代谢综合征、病程、氯丙嗪等效剂量和认知功能后，这些发现的显著性仍然存在（F=9.57，自由度=2，P<0.001）。此外，在所有患者或每个精神病组中，病程、氯丙嗪等效剂量以及阳性和阴性症状量表的五因素评分与T淋巴细胞的TL均无显著相关性。
本研究讨论了抗精神病药物对端粒酶作用的潜在机制，但需要进一步采用前瞻性设计测量端粒酶活性和TL的研究。
