Başak Nihal, Aksoy Yakup, Kaydu Ayhan, Şahin Ömer Fatih
a Selahaddin Eyyübi State Hospital , Diyarbakır , Turkey.
b Department of Anesthesiology , Bismil State Hospital , Diyarbakır , Turkey.
Libyan J Med. 2017 Dec;12(1):1313093. doi: 10.1080/19932820.2017.1313093.
To investigate the efficacy of lornoxicam in the prevention of the pain associated with propofol injection.
Approval for this study was granted by the ethics committee of our hospital. Using a computer randomisation software, 120 patients undergoing elective surgery were assigned to four equal groups. In Group I (control group), immediately before anaesthesia induction, 10 ml of isotonic 0.9% NaCl solution (placebo) was administered intravenously (IV). In Groups II, III and IV, the same injection contained 2 mg, 4 mg and 8 mg of lornoxicam respectively. A tourniquet was then applied to the forearm for two minutes. Pain evaluation was made using a verbal pain score.
Differences in pain severity scores were statistically significant between Groups I and II, Groups I and III, Groups I and IV and between Groups II and III (p < 0.05). However, no significant difference was determined between Groups III and IV (p = 0.401).
In all groups administered with lornoxicam, there was a significant reduction in the severity of pain associated with propofol injection, in comparison with the control group. Maximum effect is obtained with a dose of 4 mg.
探讨氯诺昔康预防丙泊酚注射相关疼痛的疗效。
本研究获我院伦理委员会批准。使用计算机随机软件，将120例行择期手术的患者分为四组，每组人数相等。第一组（对照组）在麻醉诱导前即刻静脉注射10 ml等渗0.9%氯化钠溶液（安慰剂）。第二组、第三组和第四组的相同注射液分别含有2 mg、4 mg和8 mg氯诺昔康。然后在前臂使用止血带两分钟。采用言语疼痛评分法进行疼痛评估。
第一组与第二组、第一组与第三组、第一组与第四组以及第二组与第三组之间的疼痛严重程度评分差异有统计学意义（p < 0.05）。然而，第三组与第四组之间未发现显著差异（p = 0.401）。
与对照组相比，所有给予氯诺昔康的组中，丙泊酚注射相关的疼痛严重程度均显著降低。4 mg剂量可获得最大效果。
