Francis M J, Fry C M, Rowlands D J, Brown F
Department of Virology, Wellcome Biotechnology Ltd, Beckenham, Kent, U.K.
J Gen Virol. 1988 Oct;69 ( Pt 10):2483-91. doi: 10.1099/0022-1317-69-10-2483.
In cross-immunization studies using foot-and-mouth disease virus (FMDV) antigens and a synthetic peptide, from a region within virus coat protein VP1, it has been shown that intact virus will prime the immune system for intact virus, virus subunits and synthetic peptide but not for disrupted virus. In contrast, peptide will prime for a response to peptide and virus subunits but not to intact virus or disrupted virus. Furthermore, studies on antibody populations in anti-virus and anti-peptide antisera demonstrated clear differences in the nature of the antibody response to the two antigens. This result is reflected in protection studies carried out on animals immunized with virus particles or peptides where there is a clearer correlation between in vitro neutralization and protection in vivo following peptide immunization. Thus, it has been shown that there are major qualitative and quantitative differences in the immune response to the FMDV particle and synthetic peptide.
在使用口蹄疫病毒（FMDV）抗原和一种合成肽（来自病毒衣壳蛋白VP1内的一个区域）进行的交叉免疫研究中，已表明完整病毒能使免疫系统对完整病毒、病毒亚基和合成肽产生免疫反应，但对裂解病毒则不能。相比之下，肽能使免疫系统对肽和病毒亚基产生反应，但对完整病毒或裂解病毒则不能。此外，对抗病毒和抗肽抗血清中抗体群体的研究表明，针对这两种抗原的抗体反应性质存在明显差异。这一结果反映在用病毒颗粒或肽免疫动物的保护研究中，肽免疫后体外中和作用与体内保护之间的相关性更明显。因此，已表明对口蹄疫病毒颗粒和合成肽的免疫反应在质量和数量上存在主要差异。
