Francis M J, Hastings G Z, Clarke B E, Brown A L, Beddell C R, Rowlands D J, Brown F
Department of Virology, Wellcome Biotechnology Ltd, Beckenham, Kent, U.K.
Immunology. 1990 Feb;69(2):171-6.
Uncoupled peptides from all seven serotypes of foot-and-mouth disease virus (FMDV) protein VP1 have been used to elicit neutralizing antibody responses in guinea-pigs. The responses were largely serotype specific, although some significant cross-neutralization was observed. Dimeric tandem peptides have also been used to simultaneously elicit neutralizing antibodies to two different FMDV serotypes. The possible existence of structural features common to the B-cell neutralization sites or the guinea-pig helper T-cell sites within all seven peptides are analysed and discussed.
来自口蹄疫病毒（FMDV）蛋白VP1所有七种血清型的解偶联肽已被用于在豚鼠中引发中和抗体反应。尽管观察到一些显著的交叉中和作用，但这些反应在很大程度上具有血清型特异性。二聚体串联肽也已被用于同时引发针对两种不同FMDV血清型的中和抗体。本文分析并讨论了所有七种肽中B细胞中和位点或豚鼠辅助性T细胞位点可能存在的共同结构特征。
