Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Eur J Pharmacol. 2017 Dec 5;816:32-36. doi: 10.1016/j.ejphar.2017.04.030. Epub 2017 Apr 25.
The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.
先天淋巴细胞（ILC）家族包括 NK 细胞、淋巴组织诱导细胞以及“辅助”样 ILC 亚群 ILC1、ILC2 和 ILC3，它们在抵御微生物、调节炎症性疾病和参与过敏反应方面发挥着重要作用。ILC1 在受到 IL-12 和 IL-18 的刺激时会产生 IFN-γ，ILC2 在受到 IL-33 和 IL-25 的刺激时会产生 IL-5 和 IL-13，而 ILC3 在受到 IL-23 或 IL-1 的刺激时会产生 IL-17 和 IL-22。尽管很少有研究直接调查 ILC 在动脉粥样硬化中的作用，但有几项研究调查了 ILC 和辅助性 T 细胞共有的转录因子和细胞因子。在这篇综述中，我们总结了我们目前对 ILC 在动脉粥样硬化中的作用的理解，并讨论了未来的方向。
