利用巨噬细胞可塑性进行组织再生。
Harnessing macrophage plasticity for tissue regeneration.
机构信息
Department of Biomedical Engineering, University of California, Irvine, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States.
Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, United States.
出版信息
Adv Drug Deliv Rev. 2017 May 15;114:193-205. doi: 10.1016/j.addr.2017.04.012. Epub 2017 Apr 25.
Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers, and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention.
巨噬细胞是免疫系统中多功能且具有可塑性的效应细胞，为多种免疫功能做出贡献，包括清除病原体或凋亡细胞、激活和缓解炎症以及组织修复。巨噬细胞作为信号调节和放大因子发挥作用，调节其活性是控制炎症或在再生医学中诱导伤口愈合反应的一种有效方法。本文讨论了基于生物材料改变巨噬细胞活性的方法、将药物靶向巨噬细胞的方法以及将巨噬细胞作为治疗干预手段进行递送的方法。
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