Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro 76230, México.
Dermato-oncology Clinic, School of Medicine, Research Division, Universidad Nacional Autónoma de México, Av. Universidad 3000, Coyoacán, Copilco Universidad, 04510 Mexico City, México.
Nat Rev Cancer. 2017 Jul;17(7):393-394. doi: 10.1038/nrc.2017.43. Epub 2017 Apr 28.
Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations are not associated with exposure to ultraviolet (UV) light, suggesting a different disease aetiology. Further study of these subtypes is necessary to understand their risk factors and genomic architecture, and to tailor therapies and public health campaigns to benefit patients of all ethnic groups.
我们目前对黑色素瘤的大部分认识都来自于对欧洲裔人群中患者的研究，这些人群中的公共卫生、防晒措施和筛查措施大大降低了疾病死亡率。值得注意的是，在其他人群中最常见的一些黑色素瘤亚型与暴露在紫外 (UV) 线下无关，这表明其病因不同。进一步研究这些亚型对于了解其危险因素和基因组结构，以及针对所有种族的患者定制治疗和公共卫生措施是必要的。
