Sakai Kiyohiro, Matsuoka Hiromichi, Ohtake Yoichi, Makimura Chihiro, Izumi Hiroaki, Fujita Yoshihiko, Otsuka Masatomo, Tsurutani Junji, Nishio Kazuto, Nakagawa Kazuhiko, Koyama Atsuko
Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.
Department of Palliative Care Center, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.
Mol Clin Oncol. 2017 Mar;6(3):331-333. doi: 10.3892/mco.2017.1159. Epub 2017 Feb 7.
Carnitine deficiency is reportedly associated with increased pain sensation in diabetes mellitus and fibromyalgia, but the association between serum carnitine concentration and cancer pain has not been fully elucidated. We investigated the incidence of carnitine deficiency in patients with cancer pain, and examined the effect of the patients' demographic and clinical characteristics on pain intensity and carnitine deficiency. The serum carnitine concentration was measured in 50 patients with cancer pain receiving non-steroidal anti-inflammatory drugs, but not opioids. Multivariate regression analysis was used to determine the association of carnitine concentration, pain intensity, age and gender with hemoglobin and C-reactive protein (CRP) concentrations. Carnitine deficiency was detected in 9 of the patients (18.0%) and found to be significantly correlated with an elevated CRP concentration (P=0.039). In conclusion, although there does not appear to be an association between carnitine deficiency and cancer pain, it may be affected by inflammation or infection.
据报道，肉碱缺乏与糖尿病和纤维肌痛中疼痛感觉增加有关，但血清肉碱浓度与癌痛之间的关联尚未完全阐明。我们调查了癌痛患者中肉碱缺乏的发生率，并研究了患者的人口统计学和临床特征对疼痛强度和肉碱缺乏的影响。对50例接受非甾体抗炎药但未使用阿片类药物的癌痛患者测定了血清肉碱浓度。采用多变量回归分析来确定肉碱浓度、疼痛强度、年龄和性别与血红蛋白及C反应蛋白（CRP）浓度之间的关联。9例患者（18.0%）检测到肉碱缺乏，发现其与CRP浓度升高显著相关（P = 0.039）。总之，虽然肉碱缺乏与癌痛之间似乎没有关联，但它可能受炎症或感染的影响。
