腹膜透析患者肉碱缺乏症和肉碱水平降低的发生率。
Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis.
机构信息
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
Department of Nephrology, Keiai Hospital, 3-10-6, Mukaihara, Itabashi-ku, Tokyo 173-0036, Japan.
出版信息
Nutrients. 2019 Nov 4;11(11):2645. doi: 10.3390/nu11112645.
BACKGROUND
Carnitine deficiency is common in patients on dialysis. Serum free carnitine concentration is significantly lower in patients on hemodialysis (HD) than in healthy individuals. However, there are few reports on serum free carnitine concentration in patients on peritoneal dialysis (PD).
METHODS
We examined serum concentrations of total, free, and acylcarnitine and the acylcarnitine/free carnitine ratio in 34 PD and 34 age-, sex-, and dialysis duration-matched HD patients. We investigated the prevalence of carnitine deficiency and clinical factors associated with carnitine deficiency in the PD group.
RESULTS
Prevalence of carnitine deficiency was 8.8% in the PD group and 17.7% in the HD group ( = 0.283). High risk of carnitine deficiency was found in 73.5% of the PD group and 76.4% of the HD group ( = 0.604). Carnitine insufficiency was found in 82.3% of the PD group and 88.2% of HD group ( = 0.733). Multivariate analysis revealed that duration of dialysis and age were independent predictors of serum free carnitine level in the PD group.
CONCLUSIONS
The prevalence of carnitine deficiency, high risk of carnitine deficiency, and carnitine insufficiency in PD patients was 8.8%, 73.5%, and 82.3%, respectively. These rates were comparable to those in patients on HD.
背景
肉碱缺乏在透析患者中很常见。与健康个体相比，血液透析（HD）患者的血清游离肉碱浓度显著降低。然而，关于腹膜透析（PD）患者血清游离肉碱浓度的报道很少。
方法
我们检查了 34 名 PD 患者和 34 名年龄、性别和透析时间匹配的 HD 患者的总肉碱、游离肉碱和酰基肉碱浓度以及酰基肉碱/游离肉碱比值。我们调查了 PD 组肉碱缺乏的患病率以及与肉碱缺乏相关的临床因素。
结果
PD 组肉碱缺乏的患病率为 8.8%，HD 组为 17.7%（=0.283）。PD 组有 73.5%的患者存在肉碱缺乏的高风险，HD 组有 76.4%的患者存在肉碱缺乏的高风险（=0.604）。PD 组肉碱不足的患病率为 82.3%，HD 组为 88.2%（=0.733）。多变量分析显示，透析时间和年龄是 PD 患者血清游离肉碱水平的独立预测因素。
结论
PD 患者肉碱缺乏、肉碱缺乏高风险和肉碱不足的患病率分别为 8.8%、73.5%和 82.3%。这些比率与 HD 患者相当。
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