Carreras Elisa, Salomão Diva R, Nadal Jeroni, Amin Sejal R, Raja Harish, Grube Thomas J, Geraets Ryan L, Johnston Patrick B, O'Neill Brian P, Pulido Jose S
Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905 USA.
Barraquer Institute, Barcelona, Spain.
Int J Retina Vitreous. 2017 Apr 24;3:15. doi: 10.1186/s40942-017-0067-x. eCollection 2017.
To determine the occurrence of macular edema (ME) in vitreoretinal lymphoma (VRL).
Retrospective analysis of 17 patients (31 eyes) with VRL. A review of the literature was done as well.
Nine patients (15 eyes) had fluorescein angiography and/or optical coherence tomography at presentation. In the ME group (six eyes of four patients), three patients (five eyes) had prior chemotherapy and radiation. Excluding eyes with radiation retinopathy (three eyes), rate of ME was 25% (3/12). When two unirradiated fellow eyes of eyes with radiation retinopathy were also excluded, ME rate was 10% (1/10). Excluding the eyes with intraocular surgery, the rate of ME was 0%. In the group without ME (nine eyes of six patients), one patient (one eye) was treated with chemotherapy and radiation and three patients (five eyes) with chemotherapy. Review of the literature showed that the ME was found between 2 and 60% of cases, but most of the cases with ME had prior interventions.
Macular edema in VRL is not uncommon but usually related to prior interventions. Macular edema as an initial presentation of VRL is rare.
确定玻璃体视网膜淋巴瘤（VRL）中黄斑水肿（ME）的发生率。
对17例（31只眼）VRL患者进行回顾性分析。同时对文献进行了综述。
9例患者（15只眼）在初诊时进行了荧光素血管造影和/或光学相干断层扫描。在ME组（4例患者的6只眼）中，3例患者（5只眼）曾接受过化疗和放疗。排除放射性视网膜病变的眼（3只眼）后，ME发生率为25%（3/12）。当排除放射性视网膜病变眼的2只未受照射的对侧眼后，ME发生率为10%（1/10）。排除接受过眼内手术的眼后，ME发生率为0%。在无ME组（6例患者的9只眼）中，1例患者（1只眼）接受了化疗和放疗，3例患者（5只眼）接受了化疗。文献综述显示，ME在2%至60%的病例中被发现，但大多数有ME的病例都有先前的干预措施。
VRL中的黄斑水肿并不少见，但通常与先前的干预措施有关。黄斑水肿作为VRL的初始表现很少见。
