Chauhan Parul, Verma H N, Sisodia Rashmi, Kesari Kavindra Kumar
a Department of Engineering and Technology , Jaipur National University , Jaipur , India.
b Department of Zoology , University of Rajasthan , Jaipur , India.
Electromagn Biol Med. 2017;36(1):20-30. doi: 10.3109/15368378.2016.1144063. Epub 2016 Jun 30.
Man-made microwave and radiofrequency (RF) radiation technologies have been steadily increasing with the growing demand of electronic appliances such as microwave oven and cell phones. These appliances affect biological systems by increasing free radicals, thus leading to oxidative damage. The aim of this study was to explore the effect of 2.45 GHz microwave radiation on histology and the level of lipid peroxide (LPO) in Wistar rats. Sixty-day-old male Wistar rats with 180 ± 10 g body weight were used for this study. Animals were divided into two groups: sham exposed (control) and microwave exposed. These animals were exposed for 2 h a day for 35 d to 2.45 GHz microwave radiation (power density, 0.2 mW/cm). The whole-body specific absorption rate (SAR) was estimated to be 0.14 W/kg. After completion of the exposure period, rats were sacrificed, and brain, liver, kidney, testis and spleen were stored/preserved for determination of LPO and histological parameters. Significantly high level of LPO was observed in the liver (p < 0.001), brain (p < 0.004) and spleen (p < 0.006) in samples from rats exposed to microwave radiation. Also histological changes were observed in the brain, liver, testis, kidney and spleen after whole-body microwave exposure, compared to the control group. Based on the results obtained in this study, we conclude that exposure to microwave radiation 2 h a day for 35 d can potentially cause histopathology and oxidative changes in Wistar rats. These results indicate possible implications of such exposure on human health.
随着微波炉和手机等电子设备需求的不断增长，人造微波和射频（RF）辐射技术一直在稳步增加。这些设备通过增加自由基来影响生物系统，从而导致氧化损伤。本研究的目的是探讨2.45 GHz微波辐射对Wistar大鼠组织学和脂质过氧化物（LPO）水平的影响。本研究使用体重为180±10 g的60日龄雄性Wistar大鼠。将动物分为两组：假暴露组（对照组）和微波暴露组。这些动物每天暴露于2.45 GHz微波辐射（功率密度，0.2 mW/cm²）2小时，持续35天。全身比吸收率（SAR）估计为0.14 W/kg。暴露期结束后，处死大鼠，保存大脑、肝脏、肾脏、睾丸和脾脏用于测定LPO和组织学参数。在暴露于微波辐射的大鼠样本中，肝脏（p < 0.001）、大脑（p < 0.004）和脾脏（p < 0.006）中观察到LPO水平显著升高。与对照组相比，全身微波暴露后大脑、肝脏、睾丸、肾脏和脾脏也观察到组织学变化。根据本研究获得的结果，我们得出结论，每天暴露于微波辐射2小时，持续35天，可能会导致Wistar大鼠出现组织病理学和氧化变化。这些结果表明这种暴露可能对人类健康产生影响。
