Othman Haifa, Ammari Mohamed, Rtibi Kaïs, Bensaid Noura, Sakly Mohsen, Abdelmelek Hafedh
University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, Jarzouna 7021, Tunisia.
University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, Jarzouna 7021, Tunisia; University of Tunis El Manar, Higher Institute of Applied Biological Sciences of Tunis, 9, Rue Zouhair Essafi, 1006 Tunis, Tunisia.
Environ Toxicol Pharmacol. 2017 Jun;52:239-247. doi: 10.1016/j.etap.2017.04.016. Epub 2017 Apr 22.
The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2h a day throughout gestation period. Control females were subjected to the same conditions as treated group without applying WiFi radiations. After delivery, the offspring was tested for physical and neurodevelopment during its 17 postnatal days (PND), then for anxiety (PND 28) and motricity (PND 40-43), as well as for cerebral oxidative stress response and cholinesterase activity in brain and serum (PND 28 and 43). Our main results showed that the in-utero WiFi exposure impaired offspring neurodevelopment during the first seventeen postnatal days without altering emotional and motor behavior at adult age. Besides, prenatal WiFi exposure induced cerebral oxidative stress imbalance (increase in malondialdehyde level (MDA) and hydrogen peroxide (HO) levels and decrease in catalase (CAT) and superoxide dismutase (SOD) activities) at 28 but not 43days old, also the exposure affected acethylcolinesterase activity at both cerebral and seric levels. Thus, the current study revealed that maternal exposure to WiFi radiofrequencies led to various adverse neurological effects in the offspring by affecting neurodevelopment, cerebral stress equilibrium and cholinesterase activity.
本研究调查了产前暴露于传统WiFi设备的射频波对大鼠后代出生后发育和行为的影响。将十只Wistar白化病怀孕大鼠随机分为两组（n = 5）。实验组在整个妊娠期每天暴露于2.45GHz的WiFi信号下2小时。对照雌性大鼠在与处理组相同的条件下饲养，但不施加WiFi辐射。分娩后，在出生后17天（PND）对后代进行身体和神经发育测试，然后在28天（PND）测试焦虑情况，在40 - 43天（PND）测试运动能力，以及在28天和43天（PND）测试大脑氧化应激反应和大脑及血清中的胆碱酯酶活性。我们的主要结果表明，子宫内WiFi暴露在出生后的前十七天损害了后代的神经发育，但在成年期并未改变其情绪和运动行为。此外，产前WiFi暴露在28天而非43天时诱导了大脑氧化应激失衡（丙二醛（MDA）水平和过氧化氢（HO）水平升高，过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性降低），并且该暴露在大脑和血清水平上均影响乙酰胆碱酯酶活性。因此，当前研究表明，母体暴露于WiFi射频会通过影响神经发育、大脑应激平衡和胆碱酯酶活性，对后代产生各种不良神经学影响。
