Department of Nursing, Harbin Medical University, Daqing, China.
The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Environ Sci Pollut Res Int. 2023 Sep;30(42):95892-95900. doi: 10.1007/s11356-023-29159-4. Epub 2023 Aug 10.
The aim of this study is to examine the long-term effects of prenatal and early-life WIFI signal exposure on neurodevelopment and behaviors as well as biochemical alterations of Wistar rats. On the first day of pregnancy (E0), expectant rats were allocated into two groups: the control group (n = 12) and the WiFi-exposed group (WiFi group, n = 12). WiFi group was exposed to turn on WiFi for 24 h/day from E0 to postnatal day (PND) 42. The control group was exposed to turn-off WiFi at the same time. On PND7-42, we evaluated the development and behavior of the offspring, including body weight, pain threshold, and swimming ability, spatial learning, and memory among others. Also, levels of proteins involved in apoptosis were analyzed histologically in the hippocampus in response to oxidative stress. The results showed that WiFi signal exposure in utero and early life (1) increased the body weight of WiFi + M (WiFi + male) group; (2) no change in neuro-behavioral development was observed in WiFi group; (3) increased learning and memory function in WiFi + M group; (4) enhanced comparative levels of BDNF and p-CREB proteins in the hippocampus of WiFi + M group; (5) no neuronal loss or degeneration was detected, and neuronal numbers in hippocampal CA1 were no evidently differences in each group; (6) no change in the apoptosis-related proteins (caspase-3 and Bax) levels; and (7) no difference in GSH-PX and SOD activities in the hippocampus. Prenatal WiFi exposure has no effects on hippocampal CA1 neurons, oxidative equilibrium in brain, and neurodevelopment of rats. Some effects of prenatal WiFi exposure are sex dependent. Prenatal WiFi exposure increased the body weight, improved the spatial memory and learning function, and induced behavioral hyperactivity of male rats.
本研究旨在探讨产前和生命早期 WIFI 信号暴露对 Wistar 大鼠神经发育和行为以及生化改变的长期影响。在妊娠第 1 天（E0），将孕鼠分为两组：对照组（n=12）和 WIFI 暴露组（WiFi 组，n=12）。从 E0 到产后第 42 天（PND），WiFi 组每天 24 小时开启 WIFI。对照组同时关闭 WIFI。在 PND7-42 时，我们评估了后代的发育和行为，包括体重、痛阈和游泳能力、空间学习和记忆等。此外，还分析了海马组织中与氧化应激相关的凋亡蛋白水平。结果表明，宫内和生命早期（1）暴露于 WIFI 信号增加了 WiFi + M（WiFi + 雄性）组的体重；（2）WiFi 组神经行为发育无变化；（3）WiFi + M 组学习和记忆功能增强；（4）增强了海马中 BDNF 和 p-CREB 蛋白的比较水平；（5）未检测到神经元丢失或变性，各组海马 CA1 神经元数量无明显差异；（6）凋亡相关蛋白（caspase-3 和 Bax）水平无变化；（7）海马组织中 GSH-PX 和 SOD 活性无差异。产前 WIFI 暴露对大鼠海马 CA1 神经元、大脑氧化平衡和神经发育没有影响。产前 WIFI 暴露的一些影响具有性别依赖性。产前 WIFI 暴露增加了雄性大鼠的体重，改善了空间记忆和学习功能，诱导了其行为过度活跃。
