Amer Tahani, El-Baz Rizk, Mokhtar Abdel-Rahman, El-Shaer Saad, Elshazli Rami, Settin Ahmad
a Department of Zoology , College of Science, Mansoura University , Mansoura , Egypt.
b Genetics Unit , Children Hospital, Mansoura University , Mansoura , Egypt.
Arch Physiol Biochem. 2017 Dec;123(5):279-285. doi: 10.1080/13813455.2017.1320680. Epub 2017 Apr 28.
Genetic polymorphisms of IL-23 R (rs7517847) and LEP (rs7799039) have been stated to be associated with various types of human cancers. The purpose of this work is to test the association of these genetic polymorphisms with hepatocellular carcinoma (HCC) among Egyptian patients.
This study involved 150 unrelated Egyptian HCC patients in addition to 100 healthy controls from the same locality. DNA was genotyped for these genetic polymorphisms using the PCR-RFLP technique.
The frequency of the IL-23 R (rs7517847) G and LEP (rs7799039) G alleles were significantly higher among HCC patients compared to controls (p = .004 and .02). However, HCC patients with the IL-23 R GG and LEP GG genotypes showed no significant difference compared to others regarding their clinical and laboratory markers.
IL-23 R (rs7517847) and LEP (rs7799039) polymorphisms were associated with an increased risk but not affecting the clinical presentation of HCC among Egyptian patients.
白细胞介素23受体（IL-23 R，rs7517847）和瘦素（LEP，rs7799039）的基因多态性已被证实与多种人类癌症相关。本研究旨在检测这些基因多态性与埃及肝细胞癌（HCC）患者的相关性。
本研究纳入了150例无血缘关系的埃及HCC患者以及来自同一地区的100例健康对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对这些基因多态性进行基因分型。
与对照组相比，HCC患者中白细胞介素23受体（rs7517847）的G等位基因和瘦素（rs7799039）的G等位基因频率显著更高（p = 0.004和0.02）。然而，白细胞介素23受体GG基因型和瘦素GG基因型的HCC患者在临床和实验室指标方面与其他患者相比无显著差异。
白细胞介素23受体（rs7517847）和瘦素（rs7799039）基因多态性与埃及HCC患者风险增加相关，但不影响其临床表现。
