Department of Intervention, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, PR China..
Department of Intervention, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, PR China.
Genomics. 2019 Jul;111(4):930-935. doi: 10.1016/j.ygeno.2018.05.023. Epub 2018 Jun 1.
In this study, we summarized the association of IL-23R gene polymorphisms with hepatocellular carcinoma (HCC). A total of 270 HCC patients were selected as HCC group, and 251 healthy individuals served as the control group. PCR-RFLP was performed to detect IL-23R gene polymorphism, including rs17375018 and rs11805303. Survival rate and risk factors of HCC were identified. The findings suggested that IL-23R rs17375018 was correlated with genetic susceptibility to HCC, and GC haplotype was closely linked with the risk factors of HCC. Moreover, rs17375018 polymorphism was related to portal vein tumor thrombus (PVTT) and alcohol consumption in HCC patients, while prognosis was better in HCC patients with AA genotype of rs17375018 polymorphism. Lastly, GG genotype in rs17375018, PVTT and TNM stage III and IV were identified as independent risk factors for HCC. In conclusion, IL-23R rs17375018 polymorphism might serve as a prognostic factor in patients with HCC after interventional therapy.
在这项研究中，我们总结了白细胞介素 23 受体（IL-23R）基因多态性与肝细胞癌（HCC）的关联。选择了 270 名 HCC 患者作为 HCC 组，251 名健康个体作为对照组。采用 PCR-RFLP 检测 IL-23R 基因多态性，包括 rs17375018 和 rs11805303。鉴定 HCC 的生存率和危险因素。研究结果表明，IL-23R rs17375018 与 HCC 的遗传易感性相关，GC 单倍型与 HCC 的危险因素密切相关。此外，rs17375018 多态性与 HCC 患者的门静脉癌栓（PVTT）和饮酒有关，而 rs17375018 多态性 AA 基因型的 HCC 患者预后更好。最后，rs17375018 的 GG 基因型、PVTT 和 TNM 分期 III 和 IV 被确定为 HCC 的独立危险因素。总之，IL-23R rs17375018 多态性可能是 HCC 患者介入治疗后的预后因素。
