Abolhasani Foroughi Amin, Salahi Roohollah, Nikseresht Alireza, Heidari Hora, Nazeri Masoume, Khorsand Ali
1 Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz Iran.
2 Clinical Neurology Research Center, Department of Neurology, Shiraz University of Medical Sciences, Shiraz Iran.
Neuroradiol J. 2017 Aug;30(4):347-351. doi: 10.1177/1971400916678224. Epub 2017 Apr 28.
Introduction The purpose of this study was to assess whether demographic, brain anatomical regions and contrast enhancement show differences in multiple sclerosis (MS) patients with increased diffusion lesions (ID group) compared with diffusion restriction (DR group). Method MRI protocol comprised T1- and T2-weighted sequences with and without gadolinium (Gd), and sagittal three-dimensional FLAIR sequence, DWI and ADC maps were prospectively performed in 126 MS patients from January to December 2015. The investigation was conducted to evaluate differences in demographic, cord and brain regional, technical, and positive or negative Gd contrast imaging parameters in two groups of ID and DR. Statistical analysis was performed by using SPSS. Results A total of 9.6% of patients showed DR. In the DR group, 66.6% of the patients showed contrast enhancement of plaques, whereas 29.2% of the IR group showed enhancement of plaques. The most prevalent group was non-enhanced plaques in the ID group, followed by Gd-enhanced plaques in the ID group. Patients in the ID group (90.4%) were significantly more than in the DR group (9.6%). Out of the 40 patients with Gd-enhanced plaques, 80.5% was from the ID group and 19.5% from the DR group. Conclusion MRI of the brain, unlike of the cord, with Gd demonstrates significant difference in enhancement between the two groups ( p < 0.05). No significant difference was seen in demographic, cord and brain regional, and technical parameters, EDSS, disease duration, and attack rate as well as demographic and regional parameters between the ID and decrease diffusion groups ( p > 0.05).
引言 本研究的目的是评估与扩散受限组（DR组）相比，具有更多扩散病灶的多发性硬化症（MS）患者（ID组）在人口统计学、脑解剖区域和对比增强方面是否存在差异。方法 MRI方案包括有和无钆（Gd）的T1加权和T2加权序列，以及矢状位三维FLAIR序列，于2015年1月至12月对126例MS患者前瞻性地进行了弥散加权成像（DWI）和表观扩散系数（ADC）图检查。进行该研究以评估ID组和DR组在人口统计学、脊髓和脑区域、技术以及Gd对比成像参数的阳性或阴性方面的差异。使用SPSS进行统计分析。结果 共有9.6%的患者表现为扩散受限。在DR组中，66.6%的患者斑块有对比增强，而ID组中有29.2%的患者斑块有增强。ID组中最常见的是无增强斑块，其次是Gd增强斑块。ID组患者（90.4%）明显多于DR组（9.6%）。在40例Gd增强斑块患者中，80.5%来自ID组，19.5%来自DR组。结论 与脊髓不同，脑部MRI显示两组在增强方面有显著差异（p < 0.05）。在人口统计学、脊髓和脑区域以及技术参数、扩展残疾状态量表（EDSS）、病程、发作率以及ID组和扩散减低组之间的人口统计学和区域参数方面未见显著差异（p > 0.05）。
