Department of Radiology, University of Palermo, Italy.
Department of Neuroradiology, Christiana Care Health System, USA.
Neuroradiol J. 2021 Oct;34(5):470-475. doi: 10.1177/19714009211008750. Epub 2021 Apr 19.
To evaluate prospectively whether an intravenous gadolinium injection could improve the detection of the central vein sign on susceptibility-weighted imaging sequences obtained with a 1.5 T magnetic resonance scanner in patients with multiple sclerosis compared to unenhanced susceptibility-weighted images.
This prospective, institution review board-approved study included 19 patients affected by multiple sclerosis (six men; 13 women; mean age 40.8 years, range 20-74 years). Patients had the relapsing-remitting clinical subtype in 95% of cases, and only one (5%) patient had the primary progressive clinical subtype of multiple sclerosis. T2-weighted images, fluid-attenuated inversion recovery images, unenhanced and contrast-enhanced susceptibility-weighted images were evaluated in consensus by two neuroradiologists for the presence of the central vein sign. The readers were blinded to magnetic resonance imaging reports, clinical information, the presence and the localisation of focal hyperintense white matter lesions. Any discordance between readers was resolved through a joint review of the recorded images with an additional neuroradiologist.
A total of 317 multiple sclerosis lesions were analysed. The central vein sign had a higher prevalence detection rate on gadolinium-enhanced susceptibility-weighted images (272 of 317 lesions, 86%) compared to unenhanced susceptibility-weighted images (172 of 317 lesions, 54%).
Gadolinium-enhanced susceptibility-weighted imaging improves the detection rate of the central vein sign in multiple sclerosis lesions.
前瞻性评估与未增强磁敏感加权成像相比，1.5 T 磁共振扫描仪获得的磁敏感加权成像序列中静脉注射钆对比剂是否能提高多发性硬化症患者中央静脉征的检出率。
这项前瞻性、机构审查委员会批准的研究纳入了 19 名多发性硬化症患者（6 名男性；13 名女性；平均年龄 40.8 岁，范围 20-74 岁）。95%的患者为复发缓解型临床亚型，仅 1 例（5%）患者为多发性硬化原发性进展型临床亚型。两位神经放射科医生对 T2 加权图像、液体衰减反转恢复图像、未增强和增强磁敏感加权图像进行了评估，以确定中央静脉征的存在。读者对磁共振成像报告、临床资料、局灶性高信号白质病变的存在和定位均不知情。如果两位读者的意见不一致，他们将通过共同查看记录的图像并由额外的神经放射科医生进行额外评估来解决分歧。
共分析了 317 个多发性硬化病变。与未增强磁敏感加权成像相比（317 个病变中有 172 个病变，54%），增强后磁敏感加权成像上中央静脉征的检出率更高（317 个病变中有 272 个病变，86%）。
增强磁敏感加权成像可提高多发性硬化病变中央静脉征的检出率。
