Faure-Dupuy Suzanne, Lucifora Julie, Durantel David
Cancer Research Center of Lyon (CRCL), INSERM, U1052, CNRS, University of Lyon, UMR-5286, 69003 Lyon, France.
Viruses. 2017 Apr 28;9(5):95. doi: 10.3390/v9050095.
The hepatitis B virus (HBV) infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells (e.g., myeloid cells, natural killer and natural killer T-cells (NK/NKT), dendritic cells (DCs)), in resting condition. Hence, the study of the interaction between HBV and innate immune cells is instrumental to: (1) better understand the conditions of establishment and maintenance of HBV infections in this secondary lymphoid organ; (2) define the role of these innate immune cells in treatment failure and pathogenesis; and (3) design novel immune-therapeutic concepts based on the activation/restoration of innate cell functions and/or innate effectors. This review will summarize and discuss the current knowledge we have on this interplay between HBV and liver innate immunity.
乙型肝炎病毒（HBV）感染肝细胞，而肝细胞是构成人类肝脏的主要细胞类型。然而，在静息状态下，肝脏富含免疫细胞，尤其是固有免疫细胞（如髓样细胞、自然杀伤细胞和自然杀伤T细胞（NK/NKT）、树突状细胞（DC））。因此，研究HBV与固有免疫细胞之间的相互作用有助于：（1）更好地了解在这个二级淋巴器官中HBV感染的建立和维持情况；（2）明确这些固有免疫细胞在治疗失败和发病机制中的作用；（3）基于固有细胞功能和/或固有效应器的激活/恢复设计新的免疫治疗概念。本综述将总结并讨论我们目前对HBV与肝脏固有免疫之间这种相互作用的认识。
