Nomura Y, Kurata T, Saito K
Acta Otolaryngol. 1985 Mar-Apr;99(3-4):419-27. doi: 10.3109/00016488509108933.
After direct inoculation of herpes simplex virus (HSV) into the scala tympani of the guinea pig, the tectorial membrane showed various morphological changes: atrophy, roll-up and dot formation. Immunofluorescent and electronmicroscopic studies revealed that the changes were due to HSV infection. The findings were compared with those observed in the temporal bones of a 77-year-old patient who suffered from sudden deafness. The tectorial membranes of both temporal bones showed various changes identical with those observed in experimental viral labyrinthitis. This supports the view that sudden deafness in this particular patient was of viral origin. In the animal experiment, HSV antigen could be detected from the cochlea of the non-inoculated side, which was morphologically normal. Further study is required to reactivate HSV in the cochlea with latent infection. This animal can probably be used as an animal model for sudden deafness.
将单纯疱疹病毒（HSV）直接接种到豚鼠的鼓阶后，盖膜呈现出各种形态学变化：萎缩、卷起和点状形成。免疫荧光和电子显微镜研究表明，这些变化是由HSV感染引起的。将这些结果与一名77岁突发耳聋患者颞骨中的观察结果进行了比较。双侧颞骨的盖膜均呈现出与实验性病毒性迷路炎中观察到的相同的各种变化。这支持了该特定患者的突发耳聋是病毒源性的观点。在动物实验中，在形态学上正常的未接种侧耳蜗中可检测到HSV抗原。需要进一步研究激活耳蜗中潜伏感染的HSV。这种动物可能可用作突发耳聋的动物模型。
