Yılmaz Mustafa, Bozkurt Yılmaz Hatice Eylül, Şen Nazan, Altın Cihan, Tekin Abdullah, Müderrisoğlu Haldun
a Department of Cardiology , Baskent University Faculty of Medicine , Adana , Turkey.
b Department of Pulmonary Medicine , Baskent University Faculty of Medicine , Adana , Turkey.
J Asthma. 2018 Jan;55(1):50-56. doi: 10.1080/02770903.2017.1313272. Epub 2017 Apr 28.
Since asthma and atherosclerosis may share similar pathophysiological mechanism, this study is planned to investigate whether epicardial fat thickness (EFT), carotid and femoral intima media thicknesses, which are markers of subclinical atherosclerosis, are increased in patients with asthma.
The study was designed as a cross-sectional study. A total of 154 participants (83 patients with asthma and 71 healthy volunteers) were enrolled into the study. Epicardial fat, carotid, and femoral intima media thicknesses were measured and recorded in both groups. The statistical difference between the two groups was examined.
Both carotid and femoral intima media thicknesses were significantly higher in patients with asthma compared to control group (5.52 ± 0.4 mm vs. 5.36 ± 0.4 mm; p = 0.038 and 5.64 ± 0.4 mm vs. 5.46 ± 0.5 mm; p = 0.036, respectively). However, there was not a significant difference in EFT between the groups [5.9 mm (5.3-6.6; IQR = 1.3) vs. 5.6 mm (4.7-6.5; IQR = 1.8); p = 0.1]. On comparison of control group and asthma subgroups (mild, moderate, and severe), there was a statistically significant difference among these four groups in terms of carotid and femoral intima media thicknesses (p = 0.002 and p < 0.001, respectively). Subgroup analyses showed that this difference was mainly due to patients with severe asthma.
Carotid and femoral intima media thicknesses in asthmatic patients were found to be increased compared to the normal population. As a result, the risk of subclinical atherosclerosis in asthmatic patients may be high.
鉴于哮喘和动脉粥样硬化可能具有相似的病理生理机制，本研究旨在调查哮喘患者的心外膜脂肪厚度（EFT）、颈动脉和股动脉内膜中层厚度（作为亚临床动脉粥样硬化的标志物）是否增加。
本研究设计为横断面研究。共有154名参与者（83例哮喘患者和71名健康志愿者）纳入本研究。测量并记录两组的心外膜脂肪、颈动脉和股动脉内膜中层厚度。检验两组之间的统计学差异。
与对照组相比，哮喘患者的颈动脉和股动脉内膜中层厚度均显著更高（分别为5.52±0.4mm对5.36±0.4mm；p=0.038以及5.64±0.4mm对5.46±0.5mm；p=0.036）。然而，两组之间的EFT无显著差异[5.9mm（5.3 - 6.6；IQR = 1.3）对5.6mm（4.7 - 6.5；IQR = 1.8）；p = 0.1]。在对照组与哮喘亚组（轻度、中度和重度）的比较中，这四组在颈动脉和股动脉内膜中层厚度方面存在统计学显著差异（分别为p = 0.002和p < 0.001）。亚组分析表明，这种差异主要归因于重度哮喘患者。
发现哮喘患者的颈动脉和股动脉内膜中层厚度相较于正常人群增加。因此，哮喘患者亚临床动脉粥样硬化的风险可能较高。
