The Generation R Study Group, Erasmus MC, University Medical Center, 3000, CA, Rotterdam, The Netherlands.
Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, 3000, CA, Rotterdam, The Netherlands.
Int J Obes (Lond). 2022 Jun;46(6):1083-1100. doi: 10.1038/s41366-022-01091-6. Epub 2022 Feb 21.
This review aimed to examine the associations of visceral adipose tissue (VAT) with pulmonary function and asthma in children and adults, and chronic obstructive pulmonary disease (COPD) in adults.
Five databases were searched up to February 12, 2021, to identify articles that described associations of VAT with pulmonary function, asthma, and COPD. Information on participant characteristics, study design and assessment, and key findings were retrieved.
A total of 43 studies were considered eligible, of which most studies were cross-sectional and in adults. The quality of included studies was generally moderate. In adults, strong evidence was found that a higher abdominal VAT was associated with asthma, and a higher intrathoracic VAT was associated with lower forced expiratory volume in the first second and forced vital capacity. Inconclusive results were found although a substantial number of studies suggested inverse association of abdominal VAT with pulmonary function. There is a limited number of studies addressing the relationship between VAT and COPD.
The literature to date provides strong evidence in adults for the associations of higher abdominal VAT with asthma, and higher intrathoracic VAT with lower lung function parameters. Future high-quality studies are warranted that adjust sufficiently for key confounding factors such as fat distribution.
本综述旨在探讨内脏脂肪组织（VAT）与儿童和成人肺功能及哮喘，以及成人慢性阻塞性肺疾病（COPD）的相关性。
截至 2021 年 2 月 12 日，我们检索了五个数据库，以确定描述 VAT 与肺功能、哮喘和 COPD 相关性的文章。我们检索了参与者特征、研究设计和评估以及主要发现等信息。
共纳入 43 项研究，其中大多数为横断面研究且针对成年人。纳入研究的质量总体为中等。在成年人中，有强有力的证据表明，较高的腹部 VAT 与哮喘相关，而较高的胸内 VAT 与第一秒用力呼气量和用力肺活量降低相关。尽管大量研究提示腹部 VAT 与肺功能呈负相关，但结果并不明确。目前关于 VAT 与 COPD 之间关系的研究数量有限。
迄今为止的文献为成年人中较高的腹部 VAT 与哮喘相关，以及较高的胸内 VAT 与较低的肺功能参数相关提供了强有力的证据。需要未来开展高质量的研究，充分调整脂肪分布等关键混杂因素。
