Department of Nutrition, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Street, Xicheng District, Beijing 100050, China.
Appl Physiol Nutr Metab. 2017 Aug;42(8):869-875. doi: 10.1139/apnm-2016-0660. Epub 2017 Apr 29.
This study investigated the relationships of dietary intake and cardiometabolic biomarkers with insulin resistance and hypertension in rural middle-aged and elderly people in China. One hundred and eight middle-aged and elderly adults were recruited in Zhangfang village in May 2014. We measured blood pressure, anthropometric parameters, and biochemical indexes, including high-sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1), glucose, insulin, and blood lipids. Homeostasis model assessment of insulin resistance index (HOMA-IR) was assessed on the basis of fasting glucose and insulin. We recorded participant demographic characteristics, dietary intake, and lifestyle using questionnaires. Hypertensive participants had higher levels of triglycerides (TG), hsCRP, sICAM-1, body fat percentage (BF%), arm muscle circumference (AMC) and HOMA-IR than nonhypertensive individuals. Hypertensive participants had higher carbohydrate intake but lower intakes of protein and fat. Carbohydrate intake was positively correlated with hsCRP, sICAM-1, TG, BF%, and HOMA-IR, and was negatively correlated with AMC. Protein and fat intakes were negatively correlated with hsCRP and sICAM-1. Protein intake was also significantly negatively correlated with TG and HOMA-IR, and positively correlated with AMC. HOMA-IR was positively correlated with hsCRP, sICAM-1, TG and BF%, and negatively correlated with AMC. Multivariable linear regression indicated that TG, sICAM-1, and hsCRP were significantly associated with HOMA-IR. In conclusion, in a rural Chinese population, high intake of carbohydrate and low intake of fat and protein were associated with insulin resistance and hypertension, possibly by increasing inflammatory factors such as sICAM-1 and hsCRP, increasing BF% and increasing the level of plasma TG.
本研究旨在探讨膳食摄入与心血管代谢生物标志物与中国农村中老年人群胰岛素抵抗和高血压的关系。2014 年 5 月，我们在章房村招募了 108 名中老年成年人。我们测量了血压、人体测量参数和生化指标，包括高敏 C 反应蛋白（hsCRP）、可溶性细胞间黏附分子-1（sICAM-1）、葡萄糖、胰岛素和血脂。根据空腹血糖和胰岛素，我们评估了胰岛素抵抗指数（HOMA-IR）。我们使用问卷记录了参与者的人口统计学特征、膳食摄入和生活方式。与非高血压参与者相比，高血压参与者的甘油三酯（TG）、hsCRP、sICAM-1、体脂肪百分比（BF%）、臂肌周长（AMC）和 HOMA-IR 水平更高。高血压参与者的碳水化合物摄入量较高，但蛋白质和脂肪摄入量较低。碳水化合物摄入量与 hsCRP、sICAM-1、TG、BF%和 HOMA-IR 呈正相关，与 AMC 呈负相关。蛋白质和脂肪摄入量与 hsCRP 和 sICAM-1 呈负相关。蛋白质摄入量也与 TG 和 HOMA-IR 呈显著负相关，与 AMC 呈正相关。HOMA-IR 与 hsCRP、sICAM-1、TG 和 BF%呈正相关，与 AMC 呈负相关。多变量线性回归表明，TG、sICAM-1 和 hsCRP 与 HOMA-IR 显著相关。综上所述，在农村中国人群中，碳水化合物摄入较高，脂肪和蛋白质摄入较低，可能通过增加 sICAM-1 和 hsCRP 等炎症因子、增加 BF%和增加血浆 TG 水平与胰岛素抵抗和高血压有关。
