Madhav M R, David S Einstein Mariya, Kumar R S Suresh, Swathy J S, Bhuvaneshwari M, Mukherjee Amitava, Chandrasekaran N
Center for Nanobiotechnology, VIT University, Vellore, Tamilnadu 632014, India.
Center for Nanobiotechnology, VIT University, Vellore, Tamilnadu 632014, India.
Environ Toxicol Pharmacol. 2017 Jun;52:227-238. doi: 10.1016/j.etap.2017.03.013. Epub 2017 Mar 22.
Metal nanoparticles production rate and its applications have raised concerns about their release and toxicity to the aquatic and terrestrial organisms. The primary size of Copper Oxide nanoparticles (CuO NP's) was found to be 114±36nm using Scanning Electron Microscopy (SEM) and a significant increase in the hydrodynamic diameter of CuO NP was seen within 1h of interaction. The median lethal concentration (LC) values obtained from the acute toxicity studies on different life stages of Artemia salina was found to be 61.4, 35, 12.2 and 175.2mg/L for 1d, 2d, 7d old and adult, respectively. The toxicity associated changes in biochemical markers such as Catalase, Reduced glutathione and Glutathione-S-Transferase were evident. The accumulation of Cu nanoparticles into the gut of Artemia salina was the major reason for toxicity. This study demonstrate the toxicity of CuO NPs to Artemia salina, and the obtained results necessitate the detailed investigation on the possible eco-toxicological implication of these nanomaterials.
金属纳米颗粒的生产速率及其应用引发了人们对其向水生和陆地生物释放以及毒性的担忧。使用扫描电子显微镜（SEM）发现氧化铜纳米颗粒（CuO NP）的初级尺寸为114±36nm，并且在相互作用1小时内观察到CuO NP的流体动力学直径显著增加。对卤虫不同生命阶段进行急性毒性研究得到的半数致死浓度（LC）值，对于1日龄、2日龄、7日龄和成年卤虫分别为61.4、35、12.2和175.2mg/L。与毒性相关的生化标志物如过氧化氢酶、还原型谷胱甘肽和谷胱甘肽 - S - 转移酶的变化很明显。铜纳米颗粒在卤虫肠道中的积累是毒性的主要原因。本研究证明了CuO NPs对卤虫的毒性，所得结果有必要对这些纳米材料可能的生态毒理学影响进行详细研究。
