一种氯菊酯和氟虫腈固定组合制剂（Effitix）用于治疗和预防与绵羊生活在一起的犬只跳蚤感染的田间试验。

A field trial of a fixed combination of permethrin and fipronil (Effitix) for the treatment and prevention of flea infestation in dogs living with sheep.

作者信息

Chatzis Manolis K, Psemmas Dimitris, Papadopoulos Elias, Navarro Christelle, Saridomichelakis Manolis N

机构信息

Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, 224 Trikalon Str., GR-43132, Karditsa, Greece.

Laboratory of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, University Campus, GR-54124, Thessaloniki, Greece.

出版信息

Parasit Vectors. 2017 Apr 28;10(1):212. doi: 10.1186/s13071-017-2145-1.

DOI:10.1186/s13071-017-2145-1

PMID:28454576

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5410079/

Abstract

BACKGROUND

A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix) for the treatment and prevention of flea infestation in dogs living with sheep and the secondary aim was to examine the efficacy of this intervention on flea infestation, pruritus and skin lesions of the people in contact with these dogs.

METHODS

Thirty dogs living with sheep and infested by at least 10 fleas and all 80 sheep living on the same premises were randomly allocated into equal groups. Group A dogs were treated three times, every 4 weeks, with a spot-on containing 54.5% permethrin and 6.1% fipronil, group A sheep were treated, on the same days, with a pour-on containing 1% deltamethrin, whereas group B dogs were sham-treated and group B sheep were placebo-treated. Flea counting was performed at the beginning of the trial (day 0) and after 14, 28, 56 and 84 days and the first five fleas from each animal were used for species identification. At the same time points, flea infestation, pruritus and skin lesions of the people in contact with the dogs were assessed.

RESULTS

The percentage of dogs with zero flea counts was significantly higher in group A than in group B on days 14, 28, 56 and 84 and flea counts were significantly lower in group A dogs than in group B dogs at the same time points. The percent efficacy of the permethrin-fipronil combination was higher than 78% (arithmetic means) or than 96% (geometric means) throughout the study. No adverse reactions were recorded. Between the two flea species found on dogs, Ctenocephalides canis was predominant over C. felis. Flea-infected sheep were not found at the beginning or during the study and no significant changes in flea infestation, pruritus and skin lesions of the people in contact with the dogs were witnessed throughout the study.

CONCLUSIONS

A spot-on solution containing 54.5% permethrin and 6.1% fipronil is safe and effective for the treatment and prevention of C. canis and C. felis infestations in dogs living with sheep.

摘要

背景

在希腊，大量跳蚤寄生于与绵羊生活在一起的犬只身上。这项随机、双盲、安慰剂对照试验的主要目的是检验氯菊酯 - 氟虫腈组合制剂（Effitix）对与绵羊生活在一起的犬只治疗和预防跳蚤感染的效果，次要目的是检验该干预措施对接触这些犬只的人群的跳蚤感染、瘙痒和皮肤病变的效果。

方法

将30只与绵羊生活在一起且感染至少10只跳蚤的犬只以及同一养殖场的80只绵羊随机分成相等的组。A组犬只每4周接受3次含有54.5%氯菊酯和6.1%氟虫腈的滴剂治疗，A组绵羊在同一天接受含有1%溴氰菊酯的浇泼剂治疗，而B组犬只接受假治疗，B组绵羊接受安慰剂治疗。在试验开始时（第0天）以及14、28、56和84天后进行跳蚤计数，每只动物的前5只跳蚤用于物种鉴定。在相同时间点，对接触犬只的人群的跳蚤感染、瘙痒和皮肤病变进行评估。

结果

在第14、28、56和84天，A组跳蚤计数为零的犬只百分比显著高于B组，且在相同时间点A组犬只的跳蚤计数显著低于B组犬只。在整个研究过程中，氯菊酯 - 氟虫腈组合制剂的有效率高于78%（算术平均值）或96%（几何平均值）。未记录到不良反应。在犬只身上发现的两种跳蚤中，犬栉首蚤比猫栉首蚤更常见。在研究开始时和研究期间均未发现感染跳蚤的绵羊，并且在整个研究过程中未观察到接触犬只的人群的跳蚤感染、瘙痒和皮肤病变有显著变化。