氟虫腈与氯菊酯的新型组合对犬栉首蚤感染犬的持续杀灭速度和驱避作用。
Sustained speed of kill and repellency of a novel combination of fipronil and permethrin against Ctenocephalides canis flea infestations in dogs.
作者信息
Beugnet Frederic, Soll Mark, Bouhsira Emilie, Franc Michel
机构信息
Merial S.A.S., 29 Av. Tony Garnier, 69007, Lyon, France.
Service de Parasitologie, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
出版信息
Parasit Vectors. 2015 Jan 27;8:52. doi: 10.1186/s13071-015-0680-1.
BACKGROUND
Ctenocephalides canis is a major flea species in dogs in several European countries. The new topical combination of fipronil and permethrin (Frontline Tri-Act/Frontect, Merial) has been developed to control fleas, ticks, mosquitoes, sandflies and biting flies on dogs. Considering the repellent and insecticidal effects of permethrin and the insecticidal effect of fipronil, the efficacy of the combination against fleas including C. canis was expected to be rapid. The study was conducted to measure the 1-hour, 6-hour and 24-hour efficacy, as well as the repellent activity, of the fipronil-permethrin combination on treated versus untreated dogs.
METHODS
12 Beagle dogs were randomly allocated to one of two groups based on pre-treatment live flea counts. Dogs in Group 1 remained untreated whereas dogs in Group 2 were treated once on Day 0. Each dog was infested with 100 unfed adult C. canis on Days 2, 7, 14, 21 and 28. Dogs were combed for fleas 1 and 6 h after each infestation. Following this examination, fleas remaining on the liner at the bottom of each cage were collected and counted. All live fleas were placed back on each dog after the 1- and 6-hour counts. A comb-count was performed at 24 h post infestation on all dogs.
RESULTS
Treated dogs had significantly (p ≤ 0.01) lower flea counts than untreated dogs at every time point. The percent efficacy was ≥99.1% at 6 and 24 h after each weekly challenge up to the month. The 1-hour counts also showed good efficacy of 96.5%, 98.9%, 92.0%, 70.2% and 55.7% on Days 2, 7, 14, 21 and 28, respectively. The repellent efficacy, assessed on the liners at 1 h, was 86.5%, 94.9%, 79.5%, 58.4% and 43.9% on Days 2, 7, 14, 21 and 28, respectively.
CONCLUSIONS
This study demonstrates the beneficial effect of the fipronil and permethrin combination against C. canis, providing both a repellent and insecticidal effect as early as 1 h post infestation, and >99.1% efficacy calculated at 6 h during a month.
背景
犬栉首蚤是欧洲多个国家犬类身上的主要跳蚤种类。新型的非泼罗尼与氯菊酯复方外用制剂（福来恩三效/弗罗泰克，梅里亚公司）已被研发用于防治犬类身上的跳蚤、蜱虫、蚊子、白蛉和吸血蝇。鉴于氯菊酯的驱避和杀虫作用以及非泼罗尼的杀虫作用，预计该复方制剂对包括犬栉首蚤在内的跳蚤的防治效果迅速。本研究旨在测定非泼罗尼 - 氯菊酯复方制剂对已治疗和未治疗犬类的1小时、6小时和24小时防治效果以及驱避活性。
方法
根据治疗前活跳蚤计数，将12只比格犬随机分为两组。第1组犬不接受治疗，而第2组犬在第0天接受一次治疗。在第2、7、14、21和28天，每只犬感染100只未进食的成年犬栉首蚤。每次感染后1小时和6小时对犬进行梳毛以检查跳蚤。检查后，收集并计数每个笼子底部衬垫上剩余的跳蚤。在1小时和6小时计数后，将所有活跳蚤放回每只犬身上。在感染后24小时对所有犬进行梳毛计数。
结果
在每个时间点，治疗组犬的跳蚤计数均显著低于未治疗组犬（p≤0.01）。在长达一个月的每周一次攻击后，6小时和24小时的防治效果百分比均≥99.1%。在第2、7、14、21和28天，1小时计数的防治效果也分别达到了96.5%、98.9%、92.0%、70.2%和55.7%。在1小时时在衬垫上评估的驱避效果在第2、7、14、21和28天分别为86.5%、94.9%、79.5%、58.4%和43.9%。
结论
本研究证明了非泼罗尼和氯菊酯复方制剂对犬栉首蚤的有益作用，在感染后1小时即提供驱避和杀虫作用，在一个月内6小时时计算的防治效果>99.1%。
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