ESPCI Paris, PSL Research University, CNRS UMR 7615, Laboratoire Sciences et Ingénierie de la Matière Molle, 10 rue Vauquelin, 75231, Paris, Cedex 05, France.
ESPCI Paris, PSL Research University, CNRS UMR 7083, Laboratoire Gulliver, 10 rue Vauquelin, 75231, Paris, Cedex 05, France.
Sci Rep. 2017 Apr 28;7(1):1265. doi: 10.1038/s41598-017-01374-3.
Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH = 3, softens as pH is progressively raised, and eventually dissolves above pH = 6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules.
生物相容性微胶囊在制药、化妆品和农用化学等领域具有广泛的应用前景，用于靶向输送活性物质。聚合物在界面处自组装形成的胶囊能够结合对刺激的响应性、生物相容性和规模化生产。在这里，我们提出了一种在油水界面原位生成膜的一步法，该方法基于聚合物在油相和水相之间的氢键供体和受体之间的氢键络合。通过不同的方法实现了这一稳健的过程，从而使用微流控或转子-定子乳化获得了从微米级到厘米级的各种尺寸的胶囊。聚合物层表现出独特的自修复和 pH 响应特性。在 pH=3 时，膜具有粘弹性，随着 pH 值的逐渐升高而软化，并最终在 pH 值大于 6 时溶解，释放出油相。这种一步法的制备为大量功能性胶囊的制备铺平了道路。
