Li Hong, Jia Yi, Feng Xiyun, Li Junbai
School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.
Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
J Colloid Interface Sci. 2017 Feb 1;487:12-19. doi: 10.1016/j.jcis.2016.10.012. Epub 2016 Oct 5.
Inspired by the composition of adhesive proteins in mussel, a facile, low-cost, and green approach to construct robust polydopamine (PDA) microcapsules as carriers for insulin delivery is developed. The morphology and shell thickness of the capsules could be tuned by varying the concentration of dopamine or the pH of Tris-HCl buffer. The PDA capsules are stable enough for long-term storage and transportation in practical application. The fluorescent property of PDA capsules labeled with FITC is beneficial in monitoring the safety and efficacy of drug carriers. Furthermore, the PDA shell coated insulin particles exhibit pH-responsive release behavior, making them promising for the oral administration of insulin in diabetic patients.
受贻贝中粘附蛋白组成的启发，开发了一种简便、低成本且绿色的方法来构建坚固的聚多巴胺（PDA）微胶囊作为胰岛素递送载体。通过改变多巴胺浓度或Tris-HCl缓冲液的pH值，可以调节胶囊的形态和壳厚度。PDA胶囊在实际应用中足够稳定，可长期储存和运输。用FITC标记的PDA胶囊的荧光特性有助于监测药物载体的安全性和有效性。此外，涂有PDA壳的胰岛素颗粒表现出pH响应释放行为，使其有望用于糖尿病患者的胰岛素口服给药。
