Dyakonov T A, Zhou L, Wan Z, Huang B, Meng Z, Guo X, Alexander H, Moore W V, Stevenson W T
Department of Chemistry, Wichita State University, Kansas 67260-0051, USA.
Ann N Y Acad Sci. 1997 Dec 31;831:72-85. doi: 10.1111/j.1749-6632.1997.tb52185.x.
The production of microcapsules suitable for the entrapment of mammalian cell by means of polyelectrolyte complexation has, of a necessity, led to the development of novel strategies for the preparation of relatively bioinert polymers which complex efficiently under unique conditions to produce a mechanically resilient membrane with efficient transport properties. In this communication we relate a brief overview of capsule-membrane forming systems for the immunoisolation (or potential immunoisolation) of mammalian cells, which are based upon the complexation of polyelectrolyte (PE) polymers; with emphasis on precursor synthesis and relationships between precursor polymer structure and capsule membrane stability.
通过聚电解质络合制备适用于包封哺乳动物细胞的微胶囊，必然促使人们开发新的策略来制备相对生物惰性的聚合物，这些聚合物在独特条件下能有效络合，以产生具有高效传输特性的机械弹性膜。在本通讯中，我们简要概述了基于聚电解质（PE）聚合物络合的用于哺乳动物细胞免疫隔离（或潜在免疫隔离）的胶囊膜形成系统；重点介绍前体合成以及前体聚合物结构与胶囊膜稳定性之间的关系。
