Liu Caihong, Li Xiangdong, Zhang Jianpo, Yang Linxia, Li Fan, Deng Junhua, Tan Feifei, Sun Ming, Liu Yuxiu, Tian Kegong
National Research Center for Veterinary Medicine, Cuiwei Rd, High-Tech District, Luoyang, 471003, China.
Beijing Anheal Laboratories Co., Ltd., Beijing, China.
Arch Virol. 2017 Aug;162(8):2337-2344. doi: 10.1007/s00705-017-3387-0. Epub 2017 Apr 28.
A canine parainfluenza virus type 5 strain was isolated from a lung sample from a diseased dog. The genome sequene of this isolate, named HeN0718, was determined and compared tho those of other previously reported canine parainfluenza viruses. Unlike previously reported viruses, the HeN0718 strain contained several nucleotide mutations in the SH gene that led to a frame shift in the open reading frame. Phylogenetic analysis based on the complete virus genome and the P, F, and HN genes showed that HeN0718 was genetically closest to D277, a Korean strain that was isolated in 2008.
从一只患病犬的肺样本中分离出一株犬副流感病毒5型毒株。测定了该分离株（命名为HeN0718）的基因组序列，并与其他先前报道的犬副流感病毒的基因组序列进行了比较。与先前报道的病毒不同，HeN0718毒株的SH基因中存在几个核苷酸突变，导致开放阅读框发生移码。基于完整病毒基因组以及P、F和HN基因的系统发育分析表明，HeN0718在基因上与2008年分离的韩国毒株D277最为接近。
