Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Mol Cell Biochem. 2017 Oct;434(1-2):17-24. doi: 10.1007/s11010-017-3031-z. Epub 2017 Apr 28.
Hepatocellular carcinoma (HCC) is characterized by hypervascularity. Hepatic stellate cells (HSCs) play very important roles in HCC malignant progression, as these cells facilitate HCC tumorigenesis and metastasis. We demonstrated that HSCs induce angiogenesis in HCC by upregulating the expression of Gli-1, which stimulates reactive oxygen species (ROS) production and potentiates increases in HCC cell invasiveness. Resveratrol abolished HSC-induced angiogenesis and suppressed ROS production and IL-6 and CXCR4 receptor expression in HepG2 cells by down-regulating Gli-1 expression. These findings indicate that Gli-1 may be a target for the prevention of angiogenesis in HCC and that resveratrol may have beneficial effects with respect to preventing HCC progression.
肝细胞癌（HCC）的特征是血管丰富。肝星状细胞（HSCs）在 HCC 恶性进展中起着非常重要的作用，因为这些细胞促进 HCC 肿瘤发生和转移。我们证明 HSCs 通过上调 Gli-1 的表达诱导 HCC 中的血管生成，Gli-1 刺激活性氧（ROS）的产生并增强 HCC 细胞的侵袭性。白藜芦醇通过下调 Gli-1 的表达消除了 HSC 诱导的血管生成，并抑制了 HepG2 细胞中 ROS 的产生以及 IL-6 和 CXCR4 受体的表达。这些发现表明，Gli-1 可能是预防 HCC 血管生成的靶点，并且白藜芦醇可能对预防 HCC 进展具有有益作用。
