Centre for the Advancement of Sustainable Medical Innovation (CASMI), University of Oxford, Room 4403, Level 4, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
Nuffield Department of Population Health, Health Economics Research Centre, University of Oxford, Oxford, UK.
Pharmacoeconomics. 2017 Aug;35(8):793-804. doi: 10.1007/s40273-017-0511-7.
Policies such as the Cancer Drugs Fund in England assumed a societal preference to fund cancer care relative to other conditions, even if that resulted in lower health gain for the population overall.
The aim of this study was to investigate the evidence for such a preference among the UK public.
The MEDLINE, PubMed and Econlit electronic databases were searched for studies relating to preferences for prioritising cancer treatment, as well as studies relating to preferences for the characteristics of cancer (severity of disease, end-of-life). The searches were run in November 2015 and updated in March 2017. Empirical preference studies, studies of public views, and studies in English were included.
We identified 24 studies relating to cancer preferences. Two directly addressed health trade-offs in the UK-one showed a preference for health gain in cancer, while the other found no such preference but provided results consistent with population health maximisation. Other studies mostly showed support for cancer but did not require a direct health trade-off. Severity and end-of-life searches identified 12 and 6 papers, respectively, which were additional to existing reviews. There is consistent evidence that people give priority to severe illness, while results for end-of-life are mixed.
We did not find consistent support for a preference for health gains to cancer patients in the context of health maximisation. The evidence base is small and the results are highly sensitive to study design. There remains a contradiction between these findings and the popular view of cancer, and further work is required to determine the features of cancer which contribute to that view.
英国的癌症药物基金等政策假设社会倾向于为癌症治疗提供资金,而不是为其他疾病提供资金,即使这会导致总体人群的健康收益降低。
本研究旨在调查英国公众对此类偏好的证据。
我们在 MEDLINE、PubMed 和 Econlit 电子数据库中搜索了与癌症治疗优先排序偏好相关的研究,以及与癌症特征(疾病严重程度、临终)偏好相关的研究。搜索于 2015 年 11 月进行,并于 2017 年 3 月进行了更新。纳入了实证偏好研究、公众意见研究以及英文研究。
我们确定了 24 项与癌症偏好相关的研究。其中两项直接涉及英国的健康权衡——一项表明对癌症健康收益的偏好,而另一项则没有发现这种偏好,但提供的结果与人口健康最大化一致。其他研究主要支持癌症,但不需要直接的健康权衡。严重程度和临终搜索分别确定了 12 篇和 6 篇论文,这些论文是现有综述的补充。有一致的证据表明,人们优先考虑严重疾病,而临终结果则存在分歧。
我们没有发现在健康最大化的背景下,人们普遍支持对癌症患者的健康收益进行偏好。证据基础很小,结果对研究设计高度敏感。这些发现与癌症的普遍观点之间仍然存在矛盾,需要进一步的工作来确定导致这种观点的癌症特征。