Koch Sandra, Schulz Thomas F
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Biol Chem. 2017 Jul 26;398(8):857-870. doi: 10.1515/hsz-2017-0111.
Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.
卡波西肉瘤相关疱疹病毒（KSHV），即人类疱疹病毒8型（HHV8），是一种γ疱疹病毒，也是卡波西肉瘤、原发性渗出性淋巴瘤和多中心Castleman病的病原体。KSHV基因组包含一组独特的蛋白质基因，这些蛋白质与细胞干扰素调节因子具有同源性，称为病毒干扰素调节因子（vIRF）。本综述将概述KSHV及相关vIRF的致癌、抗凋亡和免疫调节特性。
