使用一种新的专门设计的问卷来评估放射性碘治疗后唾液副作用的发生率。

Incidence of salivary side effects after radioiodine treatment using a new specifically-designed questionnaire.

作者信息

Moreddu E, Baumstarck-Barrau K, Gabriel S, Fakhry N, Sebag F, Mundler O, Chossegros C, Taïeb D

机构信息

Department of Maxillofacial Surgery, la Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, 13005 Marseille, France.

Unité d'Aide Méthodologique à la Recherche Clinique et Épidémiologique, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France.

出版信息

Br J Oral Maxillofac Surg. 2017 Jul;55(6):609-612. doi: 10.1016/j.bjoms.2017.03.019. Epub 2017 Apr 26.

DOI:10.1016/j.bjoms.2017.03.019

PMID:28456449

Abstract

Sialadenitis is one of the common complications of radioiodine treatment for thyroid malignancy. The aim of this study was to evaluate the prevalence of radioiodine-induced sialadenitis and other side effects by using a self-administered questionnaire. From 1 January 2011 to 31 December 2012 all consecutive patients with a newly-established diagnosis of thyroid cancer who were treated with adjuvant radioiodine at La Timone University Hospital were sent a self-administered questionnaire on salivary complaints that had been specifically designed for this study. A total of 413 patients sent the questionnaire back, of whom 100 (24%) had experienced pain, 116 (28%) discomfort or swelling, and 147 (36%) dry mouth or xerostomia. This survey has highlighted the number of side effects of radioiodine treatment in a large group of patients and corroborates previous observations. Our new self-administered questionnaire may be useful to others for follow-up and research.

摘要

涎腺炎是甲状腺恶性肿瘤放射性碘治疗的常见并发症之一。本研究的目的是通过使用一份自行填写的问卷来评估放射性碘诱发涎腺炎及其他副作用的发生率。2011年1月1日至2012年12月31日期间，所有在拉蒂莫内大学医院接受辅助放射性碘治疗且新确诊为甲状腺癌的连续患者均收到一份专门为本研究设计的关于唾液相关不适症状的自行填写问卷。共有413名患者回复了问卷，其中100名（24%）经历过疼痛，116名（28%）有不适或肿胀，147名（36%）有口干或口腔干燥症。这项调查突出了一大群患者中放射性碘治疗的副作用数量，并证实了先前的观察结果。我们新的自行填写问卷可能对其他人进行随访和研究有用。