Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Devon, EX2 5DW, UK.
Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Devon, EX2 5DW, UK.
Ageing Res Rev. 2017 Jul;36:165-170. doi: 10.1016/j.arr.2017.04.004. Epub 2017 Apr 26.
Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed isoforms often have antagonistic function and differential temporal or spatial expression patterns, yielding enormous plasticity and adaptability to cells and increasing their ability to respond to environmental challenge. The regulation of alternative splicing is critical for numerous cellular functions in both pathological and physiological conditions, and deregulated alternative splicing is a key feature of common chronic diseases. Isoform choice is controlled by a battery of splicing regulatory proteins, which include the serine arginine rich (SRSF) proteins and the heterogeneous ribonucleoprotein (hnRNP) classes of genes. These important splicing regulators have been implicated in age-related disease, and in the ageing process itself. This review will outline the important contribution of splicing regulator proteins to ageing and age-related disease.
选择性剪接是一种共转录过程，它允许从单个基因产生多个转录本，并且正在成为基因表达的一个重要控制点。选择性表达的异构体通常具有拮抗功能和不同的时空表达模式，为细胞提供了巨大的可塑性和适应性，并增强了它们对环境挑战的反应能力。选择性剪接的调节对于病理和生理条件下的许多细胞功能都至关重要，而异常的选择性剪接是常见慢性疾病的一个关键特征。异构体的选择由一系列剪接调节蛋白控制，其中包括丝氨酸/精氨酸丰富（SRSF）蛋白和异质核核糖核蛋白（hnRNP）基因家族。这些重要的剪接调节因子与与年龄相关的疾病以及衰老过程本身有关。这篇综述将概述剪接调节蛋白对衰老和与年龄相关疾病的重要贡献。
