Léger Juliane
Unité 1141, DHU Protect, service d'endocrinologie diabétologie pédiatrique, centre de référence des maladies endocriniennes de la croissance et du développement, Institut national de la santé et de la recherche médicale (Inserm), université Paris Diderot, Sorbonne Paris Cité, hôpital Robert-Debré, Assistance publique-Hôpitaux de Paris, 48, boulevard Sérurier, 75019 Paris, France.
Ann Endocrinol (Paris). 2017 Jun;78(2):106-107. doi: 10.1016/j.ando.2017.04.008. Epub 2017 Apr 28.
The early diagnosis of short stature is essential for effective management and treatment. Investigations for children with growth failure are required to distinguish between idiopathic short stature due to physiological variants (familial short stature, and constitutional delays of growth and puberty, or both), primary causes of short stature, such as syndromic and/or genetic defects and skeletal dysplasia, and secondary growth deficits due to endocrine or other chronic disorders such as celiac disease, Crohn's disease, malnutrition, renal, anorexia nervosa or other chronic diseases.
身材矮小的早期诊断对于有效管理和治疗至关重要。对于生长发育迟缓的儿童，需要进行相关检查，以区分因生理变异导致的特发性身材矮小（家族性身材矮小、生长和青春期体质性延迟或两者皆有）、身材矮小的主要原因，如综合征性和/或基因缺陷以及骨骼发育异常，以及由内分泌或其他慢性疾病（如乳糜泻、克罗恩病、营养不良、肾脏疾病、神经性厌食症或其他慢性疾病）引起的继发性生长缺陷。
