Orozco-Hernández J P, Quintero-Moreno J F, Marín-Medina D S, Castaño-Montoya J P, Hernández-Coral P, Pineda M, Vélez J D, Villada H C, Martínez J W, Lizcano A
Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Applied Neuroscience, Neurocentro S.A., Pereira, Risaralda, Colombia.
Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Applied Neuroscience, Neurocentro S.A., Pereira, Risaralda, Colombia.
Neurologia (Engl Ed). 2019 Sep;34(7):437-444. doi: 10.1016/j.nrl.2017.02.013. Epub 2017 Apr 28.
To describe the sociodemographic and clinical characteristics of a cohort of patients with epilepsy from a reference centre in Colombia.
Cross-sectional study including patients diagnosed with epilepsy who attended our epilepsy centre (Neurocentro) between 2013 and 2016. Data were gathered from patients' medical histories.
We gathered data from a total of 354 patients diagnosed with epilepsy. Median age was 37 years; 52% were men. Seizures were focal in 57% of the patients and generalised in 38%; seizure type was not determined in 6% of the sample. The most frequent aetiology was cryptogenic (21%), followed by traumatic (14%). Median time of disease progression and age at onset were 23 and 11 years, respectively. Psychiatric comorbidities were found in 18% of the patients and 40% had some degree of cognitive impairment. Around 40% of our sample reported adverse reactions to antiepileptic drugs at some point during treatment. Antiepileptic drugs were administered in monotherapy in 36% of the patients. Around 37% had drug-resistant epilepsy and 14% underwent surgery.
Psychiatric comorbidities, cognitive impairment, adverse drug reactions, and drug-resistant epilepsy are common among epileptic patients in Colombia. Knowledge of the factors with an impact on epilepsy may lay the foundations for improving management of these patients on the administrative level and improving quality of life.
描述来自哥伦比亚一家参考中心的癫痫患者队列的社会人口学和临床特征。
横断面研究，纳入2013年至2016年间在我们的癫痫中心（神经中心）就诊的癫痫确诊患者。数据从患者病历中收集。
我们共收集了354例癫痫确诊患者的数据。中位年龄为37岁；52%为男性。57%的患者发作类型为局灶性，38%为全身性；6%的样本未确定发作类型。最常见的病因是隐源性（21%），其次是创伤性（14%）。疾病进展的中位时间和发病年龄分别为23岁和11岁。18%的患者存在精神科合并症，40%有一定程度的认知障碍。约40%的样本在治疗期间曾报告对抗癫痫药物有不良反应。36%的患者采用抗癫痫药物单药治疗。约37%患有药物难治性癫痫，14%接受了手术。
在哥伦比亚，癫痫患者中精神科合并症、认知障碍、药物不良反应和药物难治性癫痫很常见。了解影响癫痫的因素可为在管理层面改善这些患者的治疗及提高生活质量奠定基础。
