脂肪酸转运蛋白：在大脑发育、衰老和中风中的作用。
Fatty acid transporting proteins: Roles in brain development, aging, and stroke.
机构信息
State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2018 Sep;136:35-45. doi: 10.1016/j.plefa.2017.04.004. Epub 2017 Apr 21.
Abstract
Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-containing protein (Mfsd2a) play critical roles in the uptake of various fatty acids, especially polyunsaturated fatty acids. They are not only involved in neurodevelopment, but also have great impact on neurological disease, such as aging related dementia and stroke.
摘要
多不饱和脂肪酸是大脑发育所必需的，对衰老和中风有重大影响。由于脂肪酸的疏水性，脂肪酸转运相关蛋白，包括脂肪酸结合蛋白（FABP）、长链酰基辅酶 A 合成酶（ACS）、脂肪酸转运蛋白（FATPs）、脂肪酸转运蛋白（FAT/CD36）和新报道的主要易化超家族结构域蛋白（Mfsd2a），在各种脂肪酸的摄取中起着关键作用，特别是多不饱和脂肪酸。它们不仅参与神经发育，而且对神经退行性疾病，如与衰老相关的痴呆和中风有重大影响。
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