胆碱和鱼油可通过提高大脑二十二碳六烯酸（DHA）水平来改善小鼠记忆。
Choline and Fish Oil Can Improve Memory of Mice through Increasing Brain DHA Level.
作者信息
Li Jin, Jian Yaqiong, Liu Ruonan, Zhao Xianfeng, Mao Jiangyi, Wei Wei, Jiang Chenyu, Zhang Lina, Wang Yi, Zhou Peng
机构信息
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214126, China.
出版信息
Foods. 2023 Apr 26;12(9):1799. doi: 10.3390/foods12091799.
Docosahexaenoic acid (DHA) is highly enriched in the brain, and is essential for normal brain development and function. However, evidence suggests that currently used supplements, such as fish oil, do not significantly increase brain DHA levels. Therefore, this study aimed to investigate whether combined fish oil and choline supplementation could affect the type and enrich the content of DHA in the brain. The results revealed that the combined intake of fish oil and choline upregulated the expression of key transporters and receptors, including MFSD2A, FATP1, and FABP5, which increased the uptake of DHA in the brain. Additionally, this supplementation improved the synthesis and release of acetylcholine in the brain, which, in turn, enhanced the learning and memory abilities of mice. These findings suggest that the combined intake of fish oil and choline improves the bioavailability of DHA in the brain.
二十二碳六烯酸（DHA）在大脑中高度富集，对正常大脑发育和功能至关重要。然而，有证据表明，目前使用的补充剂，如鱼油，并不会显著提高大脑中的DHA水平。因此，本研究旨在调查鱼油和胆碱联合补充是否会影响大脑中DHA的类型并增加其含量。结果显示，鱼油和胆碱联合摄入上调了关键转运蛋白和受体的表达，包括MFSD2A、FATP1和FABP5，从而增加了大脑对DHA的摄取。此外，这种补充改善了大脑中乙酰胆碱的合成和释放，进而增强了小鼠的学习和记忆能力。这些发现表明，鱼油和胆碱联合摄入可提高大脑中DHA的生物利用度。
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