Queensland Brain Institute, The University of Queensland, Australia.
Queensland Brain Institute, The University of Queensland, Australia; Centre for Advanced Imaging, The University of Queensland, Australia; ARC Centre for Integrative Brain Function, Australia.
Schizophr Res. 2018 Jan;191:109-122. doi: 10.1016/j.schres.2017.04.019. Epub 2017 Apr 28.
Sensory prediction errors are fundamental brain responses that signal a violation of expectation in either the internal or external sensory environment, and are therefore crucial for survival and adaptive behaviour. Patients with schizophrenia show deficits in these internal and external sensory prediction errors, which can be measured using electroencephalography (EEG) components such as N1 and mismatch negativity (MMN), respectively. New evidence suggests that these deficits in sensory prediction errors are more widely distributed on a continuum of psychosis, whereas psychotic experiences exist to varying degrees throughout the general population. In this paper, we review recent findings in sensory prediction errors in the auditory domain across the continuum of psychosis, and discuss these in light of the predictive coding hypothesis.
感觉预测误差是大脑对内部或外部感觉环境中出现的预期违反的基本反应，因此对生存和适应性行为至关重要。精神分裂症患者在这些内部和外部感觉预测误差方面存在缺陷，可以使用脑电图 (EEG) 成分（如 N1 和失匹配负波 (MMN)）分别测量。新的证据表明，这些感觉预测误差的缺陷在精神病连续体中分布更广泛，而精神病体验在普通人群中程度不同地存在。在本文中，我们回顾了精神病连续体中听觉域的感觉预测误差的最新发现，并根据预测编码假说对其进行了讨论。
