Translational Neuroscience Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA.
Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
Adv Neurobiol. 2024;40:219-234. doi: 10.1007/978-3-031-69491-2_9.
Animal models of neuropsychiatric disorders with appropriate biomarkers can greatly inform the neurobiological basis of disorder-related deficits of cognitive and/or sensory processes. Given the genetic, physiologic, and behavioral similarities between humans and nonhuman primates (NHPs), NHP studies are monumentally important for preclinical translational research. Capitalizing on the NHP's similarities with human systems provides one of the best opportunities to gain detailed insight into the mechanisms underlying disorder-related symptoms and to accumulate a foundation of information for the development of therapeutic interventions. Here, we discuss how results from NHP studies have provided insight into the generation and modulation of select auditory biomarkers of schizophrenia including auditory steady-state responses and mismatch negativity. Since neuro-oscillatory activity has been shown to be relatively preserved across species, we highlight how incorporating the analysis of local and network-level oscillations from multiple nodes across different pathways involved in auditory processing has been used to further the precision of translational comparisons across species.
具有适当生物标志物的神经精神疾病动物模型可以极大地阐明与疾病相关的认知和/或感觉过程缺陷的神经生物学基础。鉴于人类和非人类灵长类动物（NHPs）之间在遗传、生理和行为上的相似性，NHPs 研究对于临床前转化研究至关重要。利用 NHPs 与人类系统的相似性，为深入了解与疾病相关症状的机制提供了最好的机会之一，并为治疗干预措施的发展积累了信息基础。在这里，我们讨论了 NHPs 研究的结果如何为精神分裂症的一些选择性听觉生物标志物（包括听觉稳态反应和失匹配负波）的产生和调节提供了见解。由于神经振荡活动在物种间相对保留，我们强调了如何将来自不同听觉处理途径中多个节点的局部和网络水平振荡分析结合使用，以提高跨物种转化比较的准确性。
